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C7 Gene Detail
Summary
  • Symbol
    C7
  • Name
    complement component 7
  • Synonyms
    LOC383055
  • Feature Type
    protein coding gene
  • IDs
    MGI:88235
    NCBI Gene: 109828
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:5018244-5093222 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 1.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1832 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88235
 protein coding gene Chr15:5017232-5093230 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021689
 protein coding gene Chr15:1876241-1958281 (-)
A/J MGP_AJ_G0021649
 protein coding gene Chr15:1886648-1964897 (-)
AKR/J MGP_AKRJ_G0021627
 protein coding gene Chr15:1866418-1942383 (-)
BALB/cJ MGP_BALBcJ_G0021656
 protein coding gene Chr15:1823602-1901823 (-)
C3H/HeJ MGP_C3HHeJ_G0021432
 protein coding gene Chr15:1889694-1971736 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022095
 protein coding gene Chr15:1964392-2045218 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019633
 protein coding gene Chr15:1643980-1713272 (-)
CAST/EiJ MGP_CASTEiJ_G0020949
 protein coding gene Chr15:1863997-1948966 (-)
CBA/J MGP_CBAJ_G0021401
 protein coding gene Chr15:1997621-2080784 (-)
DBA/2J MGP_DBA2J_G0021525
 protein coding gene Chr15:1833369-1908100 (-)
FVB/NJ MGP_FVBNJ_G0021503
 protein coding gene Chr15:1775009-1848170 (-)
LP/J MGP_LPJ_G0021593
 protein coding gene Chr15:1812189-1894123 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021529
 protein coding gene Chr15:2114352-2201809 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022118
 protein coding gene Chr15:1872103-1949057 (-)
PWK/PhJ MGP_PWKPhJ_G0020692
 protein coding gene Chr15:1836362-1917480 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020530
 protein coding gene Chr15:1838119-1915468 (-)
WSB/EiJ MGP_WSBEiJ_G0021004
 protein coding gene Chr15:1812891-1888972 (-)



Homology
more
  • Human Ortholog
    C7, complement C7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C7, complement C7
  • Links
    NCBI Gene ID: 730
    neXtProt AC: NX_P10643
    UniProt: P10643

  • Chr Location
    5p13.1; chr5:40909492-41020216 (+)  GRCh38
  • MGI Vertebrate Homology
    C7 stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: C7
  • Gene Tree
    C7
Human Diseases
more
  • Diseases
    1 with human C7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    2
  • cDNA Data
    1
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079105 Ensembl Gene Model | MGI Sequence Detail 74979 C57BL/6J ±  kb
    transcript ENSMUST00000110689 Ensembl | MGI Sequence Detail 2676 Not Applicable  
    polypeptide ENSMUSP00000106317 Ensembl | MGI Sequence Detail 845 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR048827 Complement component C7, FIM2 N-terminal domain
      IPR048825 Complement component C7, Kazal domain
      IPR003884 Factor I / membrane attack complex
      IPR040729 Kazal-type serine protease inhibitor domain
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR001862 Membrane attack complex component/perforin/complement C9
      IPR020863 Membrane attack complex component/perforin domain, conserved site
      IPR020864 Membrane attack complex component/perforin (MACPF) domain
      IPR000436 Sushi/SCR/CCP domain
      IPR035976 Sushi/SCR/CCP superfamily
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-1713, MGI:2686084
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:7901 Orren A, et al., Close linkage between mouse genes determining the two forms of complement component C6 and component C7, and cis action of a C6 regulatory gene. Immunogenetics. 1985;21(6):591-9
    • Latest
      J:358079 Zelek WM, et al., Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model. Brain. 2024 Aug 31;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory