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Camk2b Gene Detail
Summary
  • Symbol
    Camk2b
  • Name
    calcium/calmodulin-dependent protein kinase II, beta
  • Synonyms
    CaMK II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88257
    NCBI Gene: 12323
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5919644-6016362 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.89 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2146 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88257
 protein coding gene Chr11:5919642-6016401 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018014
 protein coding gene Chr11:3064160-3157810 (-)
A/J MGP_AJ_G0017987
 protein coding gene Chr11:2942598-3035624 (-)
AKR/J MGP_AKRJ_G0017951
 protein coding gene Chr11:3090570-3185002 (-)
BALB/cJ MGP_BALBcJ_G0017955
 protein coding gene Chr11:2930774-3021627 (-)
C3H/HeJ MGP_C3HHeJ_G0017768
 protein coding gene Chr11:2965892-3058931 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018407
 protein coding gene Chr11:3142571-3242742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016065
 protein coding gene Chr11:2839786-2931140 (-)
CAST/EiJ MGP_CASTEiJ_G0017330
 protein coding gene Chr11:2938778-3035730 (-)
CBA/J MGP_CBAJ_G0017743
 protein coding gene Chr11:3527349-3636328 (-)
DBA/2J MGP_DBA2J_G0017853
 protein coding gene Chr11:2846710-2944012 (-)
FVB/NJ MGP_FVBNJ_G0017845
 protein coding gene Chr11:2873560-2965267 (-)
LP/J MGP_LPJ_G0017924
 protein coding gene Chr11:3141993-3236043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017871
 protein coding gene Chr11:3123927-3217438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018447
 protein coding gene Chr11:3107191-3197665 (-)
PWK/PhJ MGP_PWKPhJ_G0017110
 protein coding gene Chr11:2868160-2971593 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016907
 protein coding gene Chr11:3063480-3155738 (-)
WSB/EiJ MGP_WSBEiJ_G0017384
 protein coding gene Chr11:2939685-3035930 (-)



Homology
more
  • Human Ortholog
    CAMK2B, calcium/calmodulin dependent protein kinase II beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAMK2B, calcium/calmodulin dependent protein kinase II beta
  • Synonyms
    CAM2, CAMK2, CAMKB, CaMKIIbeta, MRD54
  • Links
    NCBI Gene ID: 816
    neXtProt AC: NX_Q13554
    UniProt: Q13554

  • Chr Location
    7p13; chr7:44210019-44334577 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CAMK2B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 5 alleles in 5 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reversal of plasticity direction at parallel fiber-Purkinje cell synapses. Mice homozygous for a different null allele show motor impairments, including ataxia, altered body mass composition, a reduction in anxiety-related behavior, and cognitive deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1027
  • Tissues
    103
  • cDNA Data
    53
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057897 Ensembl Gene Model | MGI Sequence Detail 96719 C57BL/6J ±  kb
    transcript ENSMUST00000019133 Ensembl | MGI Sequence Detail 2223 Not Applicable  
    polypeptide ENSMUSP00000019133 Ensembl | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000003200 calcium/calmodulin-dependent protein kinase type II subunit beta
      (term hierarchy)
    • EC
      2.7.11.17
    • InterPro Domains
      IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
      IPR032710 NTF2-like domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      P28652 9 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 2
      cDNA 54
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1744
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 23
      Gene Ontology 18
      Phenotypes 19
    • Earliest
      J:1487 Karls U, et al., Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant. Mol Cell Biol. 1992 Aug;12(8):3644-52
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory