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Cd27 Gene Detail
Summary
  • Symbol
    Cd27
  • Name
    CD27 antigen
  • Synonyms
    Cd27, S152, Tnfrsf7, Tp55
  • Feature Type
    protein coding gene
  • IDs
    MGI:88326
    NCBI Gene: 21940
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125209585-125213973 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88326
 protein coding gene Chr6:125209583-125214014 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031293
 protein coding gene Chr6:128573572-128577949 (-)
A/J MGP_AJ_G0031263
 protein coding gene Chr6:123718567-123722974 (-)
AKR/J MGP_AKRJ_G0031191
 protein coding gene Chr6:127098586-127102941 (-)
BALB/cJ MGP_BALBcJ_G0031271
 protein coding gene Chr6:123315947-123320299 (-)
C3H/HeJ MGP_C3HHeJ_G0030994
 protein coding gene Chr6:127167498-127171849 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031727
 protein coding gene Chr6:131962700-131967079 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028876
 protein coding gene Chr6:120928764-120933203 (-)
CAST/EiJ MGP_CASTEiJ_G0030375
 protein coding gene Chr6:127374726-127380902 (-)
CBA/J MGP_CBAJ_G0030955
 protein coding gene Chr6:137009190-137013544 (-)
DBA/2J MGP_DBA2J_G0031111
 protein coding gene Chr6:122650455-122654817 (-)
FVB/NJ MGP_FVBNJ_G0031061
 protein coding gene Chr6:121563781-121568136 (-)
LP/J MGP_LPJ_G0031191
 protein coding gene Chr6:128731653-128736003 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031099
 protein coding gene Chr6:141040636-141044996 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031762
 protein coding gene Chr6:127000349-127004727 (-)
PWK/PhJ MGP_PWKPhJ_G0030090
 protein coding gene Chr6:120894340-120898776 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029919
 protein coding gene Chr6:125074932-125079808 (-)
WSB/EiJ MGP_WSBEiJ_G0030460
 protein coding gene Chr6:127368414-127372804 (-)



Homology
more
  • Human Ortholog
    CD27, CD27 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD27, CD27 molecule
  • Synonyms
    S152, S152. LPFS2, T14, TNFRSF7, Tp55
  • Links
    NCBI Gene ID: 939
    neXtProt AC: NX_P26842
    UniProt: P26842

  • Chr Location
    12p13.31; chr12:6443892-6451718 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD27 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a normal phenotype. However, T-cell development immune responses are abnormal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    47
  • cDNA Data
    20
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030336 Ensembl Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
    transcript ENSMUST00000032486 Ensembl | MGI Sequence Detail 1559 Not Applicable  
    polypeptide ENSMUSP00000032486 Ensembl | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 8
      cDNA 20
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1844
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 56
    • Earliest
      J:4937 Gravestein LA, et al., Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur J Immunol. 1993 Apr;23(4):943-50
    • Latest
      J:350581 Englebert K, et al., The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis. Cell Rep. 2024 Feb 20;43(3):113824
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory