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Cdh1 Gene Detail
Summary
  • Symbol
    Cdh1
  • Name
    cadherin 1
  • Synonyms
    E-cad, Ecad, E-cadherin, L-CAM, UM, uvomorulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88354
    NCBI Gene: 12550
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:107329983-107396878 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.18 cM, cytoband D
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1734 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88354
 protein coding gene Chr8:107329982-107396879 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034085
 protein coding gene Chr8:108956540-109027659 (+)
A/J MGP_AJ_G0034066
 protein coding gene Chr8:104610284-104677886 (+)
AKR/J MGP_AKRJ_G0033992
 protein coding gene Chr8:107656100-107724600 (+)
BALB/cJ MGP_BALBcJ_G0034059
 protein coding gene Chr8:104805543-104874061 (+)
C3H/HeJ MGP_C3HHeJ_G0033771
 protein coding gene Chr8:108387288-108454764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034579
 protein coding gene Chr8:112966328-113038535 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031521
 protein coding gene Chr8:97729491-97798439 (+)
CAST/EiJ MGP_CASTEiJ_G0033097
 protein coding gene Chr8:107899502-107967607 (+)
CBA/J MGP_CBAJ_G0033744
 protein coding gene Chr8:116600309-116672143 (+)
DBA/2J MGP_DBA2J_G0033899
 protein coding gene Chr8:103948202-104015596 (+)
FVB/NJ MGP_FVBNJ_G0033844
 protein coding gene Chr8:102885663-102953316 (+)
LP/J MGP_LPJ_G0033990
 protein coding gene Chr8:109165150-109234658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033888
 protein coding gene Chr8:119760062-119828868 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034597
 protein coding gene Chr8:107587872-107656480 (+)
PWK/PhJ MGP_PWKPhJ_G0032799
 protein coding gene Chr8:103357932-103425592 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032639
 protein coding gene Chr8:106308022-106378413 (+)
WSB/EiJ MGP_WSBEiJ_G0033213
 protein coding gene Chr8:108291719-108362591 (+)



Homology
more
  • Human Ortholog
    CDH1, cadherin 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH1, cadherin 1
  • Synonyms
    Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM, UVO
  • Links
    NCBI Gene ID: 999
    neXtProt AC: NX_P12830
    UniProt: P12830

  • Chr Location
    16q22.1; chr16:68737292-68835537 (+)  GRCh38
Human Diseases
more
  • Diseases
    14 with human CDH1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 13 alleles in 10 genetic backgrounds
    38 phenotypes from multigenic genotypes
    2 images
    152 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In mutant homozygotes, adhesive cells of the morula dissociate shortly after initial compaction, probably due to depletion of maternal protein. Mutant embryos fail to form a trophectodermal epithelium or blastocyst cavity, and die near implantation time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    137
  • GO References
    110
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000303 Ensembl Gene Model | MGI Sequence Detail 66896 C57BL/6J ±  kb
    transcript ENSMUST00000000312 Ensembl | MGI Sequence Detail 4430 Not Applicable  
    polypeptide ENSMUSP00000000312 Ensembl | MGI Sequence Detail 884 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 336
      Genomic 9
      cDNA 289
      Primer pair 25
      Other 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15349, MGD-MRK-1881, MGD-MRK-19360, MGI:2142457
    References
    more
    • Summaries
      All 1917
      Developmental Gene Expression 1538
      Diseases 2
      Gene Ontology 110
      Phenotypes 152
    • Earliest
      J:31272 Peyrieras N, et al., Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6274-7
    • Latest
      J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory