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Crabp2 Gene Detail
Summary
  • Symbol
    Crabp2
  • Name
    cellular retinoic acid binding protein II
  • Synonyms
    Crabp-2, CrabpII
  • Feature Type
    protein coding gene
  • IDs
    MGI:88491
    NCBI Gene: 12904
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87856000-87860679 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88491
 protein coding gene Chr3:87855973-87860683 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027376
 protein coding gene Chr3:88081869-88086575 (+)
A/J MGP_AJ_G0027340
 protein coding gene Chr3:85091792-85096503 (+)
AKR/J MGP_AKRJ_G0027306
 protein coding gene Chr3:87184993-87189715 (+)
BALB/cJ MGP_BALBcJ_G0027349
 protein coding gene Chr3:85186040-85190766 (+)
C3H/HeJ MGP_C3HHeJ_G0027092
 protein coding gene Chr3:87455623-87460319 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027795
 protein coding gene Chr3:91323265-91327975 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025148
 protein coding gene Chr3:80714763-80719483 (+)
CAST/EiJ MGP_CASTEiJ_G0026538
 protein coding gene Chr3:87665702-87672508 (+)
CBA/J MGP_CBAJ_G0027067
 protein coding gene Chr3:94414025-94418756 (+)
DBA/2J MGP_DBA2J_G0027203
 protein coding gene Chr3:84582824-84587542 (+)
FVB/NJ MGP_FVBNJ_G0027172
 protein coding gene Chr3:82855539-82860250 (+)
LP/J MGP_LPJ_G0027311
 protein coding gene Chr3:89047917-89052620 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027191
 protein coding gene Chr3:100659952-100664694 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027853
 protein coding gene Chr3:86940379-86944905 (+)
PWK/PhJ MGP_PWKPhJ_G0026271
 protein coding gene Chr3:84378481-84383390 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026089
 protein coding gene Chr3:86120587-86125306 (+)
WSB/EiJ MGP_WSBEiJ_G0026618
 protein coding gene Chr3:87298805-87304330 (+)



Homology
more
  • Human Ortholog
    CRABP2, cellular retinoic acid binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRABP2, cellular retinoic acid binding protein 2
  • Synonyms
    CRABP-II, RBP6
  • Links
    NCBI Gene ID: 1382
    neXtProt AC: NX_P29373
    UniProt: P29373

  • Chr Location
    1q23.1; chr1:156699606-156705816 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations may exhibit an additional postaxial digit, usually on a single forepaw. Penetrance is dependent on the genetic background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1471
  • Tissues
    351
  • cDNA Data
    68
  • Literature Summary
    59
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12904 NCBI Gene Model | MGI Sequence Detail 4680 C57BL/6J ±  kb
    transcript NM_007759 RefSeq | MGI Sequence Detail 900 C57BL/6  
    polypeptide P22935 UniProt | EBI | MGI Sequence Detail 138 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      Genomic 1
      cDNA 70
      Primer pair 9
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2127, MGD-MRK-2129, MGI:2139840
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 59
      Diseases 1
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:20074 Giguere V, et al., Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6233-7
    • Latest
      J:350500 Kibalnyk Y, et al., The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function. Nat Commun. 2024 Jul 1;15(1):4632
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory