About   Help   FAQ
Cryba1 Gene Detail
Summary
  • Symbol
    Cryba1
  • Name
    crystallin, beta A1
  • Synonyms
    BA3/A1, Cryb
  • Feature Type
    protein coding gene
  • IDs
    MGI:88518
    NCBI Gene: 12957
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:77609441-77616109 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B-C1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    206 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88518
 protein coding gene Chr11:77609440-77616119 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018754
 protein coding gene Chr11:78659759-78667762 (-)
A/J MGP_AJ_G0018720
 protein coding gene Chr11:75668823-75675506 (-)
AKR/J MGP_AKRJ_G0018690
 protein coding gene Chr11:77969522-77976190 (-)
BALB/cJ MGP_BALBcJ_G0018694
 protein coding gene Chr11:76064254-76070900 (-)
C3H/HeJ MGP_C3HHeJ_G0018507
 protein coding gene Chr11:78004001-78010669 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019145
 protein coding gene Chr11:81130875-81138857 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016780
 protein coding gene Chr11:72644008-72650980 (-)
CAST/EiJ MGP_CASTEiJ_G0018061
 protein coding gene Chr11:78414281-78420997 (-)
CBA/J MGP_CBAJ_G0018477
 protein coding gene Chr11:84661219-84670907 (-)
DBA/2J MGP_DBA2J_G0018586
 protein coding gene Chr11:75255749-75262517 (-)
FVB/NJ MGP_FVBNJ_G0018576
 protein coding gene Chr11:74835701-74842338 (-)
LP/J MGP_LPJ_G0018657
 protein coding gene Chr11:79211775-79218423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018602
 protein coding gene Chr11:85108233-85116349 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019185
 protein coding gene Chr11:78194311-78200952 (-)
PWK/PhJ MGP_PWKPhJ_G0017832
 protein coding gene Chr11:76017379-76024188 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017623
 protein coding gene Chr11:77792179-77798811 (-)
WSB/EiJ MGP_WSBEiJ_G0018114
 protein coding gene Chr11:78012031-78019489 (-)



Homology
more
  • Human Ortholog
    CRYBA1, crystallin beta A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYBA1, crystallin beta A1
  • Synonyms
    CRYB1, CTRCT10
  • Links
    NCBI Gene ID: 1411
    neXtProt AC: NX_P05813
    UniProt: P05813

  • Chr Location
    17q11.2; chr17:29246859-29254494 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cryba1 mouse models; 2 with human CRYBA1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    8 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele exhibit microphthalmia, congenital nuclear cataracts, persistent hyaloid artery, and lens defects including impaired lysosomal cargo clearance, increased calcium level, and cytoskeletal defects. Homozygotes for an ENU allele show microphthalmia and total cataracts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    20
  • cDNA Data
    210
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000724 Ensembl Gene Model | MGI Sequence Detail 6669 C57BL/6J ±  kb
    transcript ENSMUST00000078623 Ensembl | MGI Sequence Detail 778 Not Applicable  
    polypeptide ENSMUSP00000077693 Ensembl | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 219
      Genomic 2
      cDNA 211
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2165, MGD-MRK-2167
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 23
      Diseases 2
      Gene Ontology 4
      Phenotypes 26
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:342582 Joseph R, et al., Lens-specific betaA3/A1-conditional knockout mice: Phenotypic characteristics and calpain activation causing protein degradation and insolubilization. PLoS One. 2023;18(3):e0281386
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory