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Cryge Gene Detail
Summary
  • Symbol
    Cryge
  • Name
    crystallin, gamma E
  • Synonyms
    Cryg-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:88525
    NCBI Gene: 12968
  • Member of
    Cryg cluster
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:65087713-65090308 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.80 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88525
 protein coding gene Chr1:65087713-65090783 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016101
 protein coding gene Chr1:65238764-65241390 (-)
A/J MGP_AJ_G0016084
 protein coding gene Chr1:62944579-62947245 (-)
AKR/J MGP_AKRJ_G0016041
 protein coding gene Chr1:64705168-64707819 (-)
BALB/cJ MGP_BALBcJ_G0016039
 protein coding gene Chr1:63040676-63043183 (-)
C3H/HeJ MGP_C3HHeJ_G0015871
 protein coding gene Chr1:64979391-64982438 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016492
 protein coding gene Chr1:67766634-67770385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014213
 protein coding gene Chr1:58999736-59001392 (-)
CAST/EiJ MGP_CASTEiJ_G0015454
 protein coding gene Chr1:64246093-64248768 (-)
CBA/J MGP_CBAJ_G0015843
 protein coding gene Chr1:69972090-69974788 (-)
DBA/2J MGP_DBA2J_G0015944
 protein coding gene Chr1:62345900-62348617 (-)
FVB/NJ MGP_FVBNJ_G0015947
 protein coding gene Chr1:61620174-61622830 (-)
LP/J MGP_LPJ_G0016016
 protein coding gene Chr1:66138889-66141520 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015967
 protein coding gene Chr1:72816402-72820945 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016539
 protein coding gene Chr1:64689420-64692071 (-)
PWK/PhJ MGP_PWKPhJ_G0015251
 protein coding gene Chr1:62626075-62627865 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015020
 protein coding gene Chr1:64172697-64175250 (-)
WSB/EiJ MGP_WSBEiJ_G0015516
 protein coding gene Chr1:64395808-64399233 (-)



Homology
more
  • Human Ortholog
    CRYGD, crystallin gamma D
  • Vertebrate Orthologs
    31
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYGD, crystallin gamma D
  • Synonyms
    CACA, CCA3, CCP, CRYG4, cry-g-D, CTRCT4, PCC
  • Links
    NCBI Gene ID: 1421
    neXtProt AC: NX_P07320
    UniProt: P07320

  • Chr Location
    2q33.3; chr2:208121607-208124524 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cryge mouse models; 2 with human CRYGD associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 10 alleles in 10 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene produce severe, nuclear and zonular cataracts with microphthalmia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    40
  • cDNA Data
    199
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070870 Ensembl Gene Model | MGI Sequence Detail 2596 C57BL/6J ±  kb
    transcript ENSMUST00000087359 Ensembl | MGI Sequence Detail 631 Not Applicable  
    polypeptide ENSMUSP00000084617 Ensembl | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 208
      Genomic 2
      cDNA 201
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2175, MGD-MRK-2180
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 5
      Phenotypes 36
    • Earliest
      J:30723 Deol MS, et al., 10.44. A new gene causing cerebral degeneration in the mouse. 1963;1:183-4 (Abstr.)
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory