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Csnk2a1 Gene Detail
Summary
  • Symbol
    Csnk2a1
  • Name
    casein kinase 2, alpha 1 polypeptide
  • Synonyms
    CK2, Csnk2a1-rs4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88543
    NCBI Gene: 12995
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152068759-152123772 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    739 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88543
 protein coding gene Chr2:152068468-152123772 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026653
 protein coding gene Chr2:156755246-156808559 (+)
A/J MGP_AJ_G0026619
 protein coding gene Chr2:150510841-150561615 (+)
AKR/J MGP_AKRJ_G0026589
 protein coding gene Chr2:154904018-154958336 (+)
BALB/cJ MGP_BALBcJ_G0026628
 protein coding gene Chr2:150822262-150873608 (+)
C3H/HeJ MGP_C3HHeJ_G0026371
 protein coding gene Chr2:155294824-155343635 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027077
 protein coding gene Chr2:161331260-161389042 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024448
 protein coding gene Chr2:144108220-144155839 (+)
CAST/EiJ MGP_CASTEiJ_G0025832
 protein coding gene Chr2:155515061-155563390 (+)
CBA/J MGP_CBAJ_G0026349
 protein coding gene Chr2:167232287-167293511 (+)
DBA/2J MGP_DBA2J_G0026485
 protein coding gene Chr2:149729497-149781351 (+)
FVB/NJ MGP_FVBNJ_G0026450
 protein coding gene Chr2:148169733-148221577 (+)
LP/J MGP_LPJ_G0026589
 protein coding gene Chr2:156926550-156978611 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026472
 protein coding gene Chr2:171358167-171411439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027132
 protein coding gene Chr2:154778808-154831527 (+)
PWK/PhJ MGP_PWKPhJ_G0025566
 protein coding gene Chr2:149247943-149299261 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025369
 protein coding gene Chr2:153622376-153669861 (+)
WSB/EiJ MGP_WSBEiJ_G0025902
 protein coding gene Chr2:155713533-155764579 (+)



Homology
more
  • Human Ortholog
    CSNK2A1, casein kinase 2 alpha 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSNK2A1, casein kinase 2 alpha 1
  • Synonyms
    CK2A1, Cka1, Cka2, CKII, OCNDS
  • Links
    NCBI Gene ID: 1457
    neXtProt AC: NX_P68400
    UniProt: P68400

  • Chr Location
    20p13; chr20:472498-543835 (-)  GRCh38
  • Human Ortholog
    CSNK2A3, casein kinase 2 alpha 3
  • Synonyms
    CSNK2A1P
  • Links
    NCBI Gene ID: 283106
    neXtProt AC: NX_Q8NEV1
    UniProt: Q8NEV1

  • Chr Location
    11p15.4; chr11:11351942-11353250 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1038
  • Tissues
    247
  • cDNA Data
    118
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074698 Ensembl Gene Model | MGI Sequence Detail 55014 C57BL/6J ±  kb
    transcript ENSMUST00000099224 Ensembl | MGI Sequence Detail 4206 Not Applicable  
    polypeptide ENSMUSP00000096829 Ensembl | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 3
      cDNA 120
      Primer pair 3
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-2201, MGI:894650
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 19
      Gene Ontology 15
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:332820 Merholz M, et al., In Skeletal Muscle Fibers, Protein Kinase Subunit CSNK2A1/CK2alpha Is Required for Proper Muscle Homeostasis and Structure and Function of Neuromuscular Junctions. Cells. 2022 Dec 7;11(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory