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Csnk2b Gene Detail
Summary
  • Symbol
    Csnk2b
  • Name
    casein kinase 2, beta polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:88548
    NCBI Gene: 13001
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35335172-35341029 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88548
 protein coding gene Chr17:35335171-35341029 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023619
 protein coding gene Chr17:35257364-35263211 (-)
A/J MGP_AJ_G0023579
 protein coding gene Chr17:34089862-34095748 (-)
AKR/J MGP_AKRJ_G0023547
 protein coding gene Chr17:34564703-34572044 (-)
BALB/cJ MGP_BALBcJ_G0023585
 protein coding gene Chr17:34228526-34234368 (-)
C3H/HeJ MGP_C3HHeJ_G0023346
 protein coding gene Chr17:34964603-34971551 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024024
 protein coding gene Chr17:36597017-36604098 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021505
 protein coding gene Chr17:31858372-31864233 (-)
CAST/EiJ MGP_CASTEiJ_G0022842
 protein coding gene Chr17:34961892-34967707 (-)
CBA/J MGP_CBAJ_G0023324
 protein coding gene Chr17:38100264-38110437 (-)
DBA/2J MGP_DBA2J_G0023452
 protein coding gene Chr17:33413612-33419403 (-)
FVB/NJ MGP_FVBNJ_G0023419
 protein coding gene Chr17:33251551-33257575 (-)
LP/J MGP_LPJ_G0023529
 protein coding gene Chr17:35585332-35592621 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023441
 protein coding gene Chr17:37038230-37045138 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024069
 protein coding gene Chr17:34784848-34790495 (-)
PWK/PhJ MGP_PWKPhJ_G0022590
 protein coding gene Chr17:32246798-32252740 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022410
 protein coding gene Chr17:32799412-32805731 (-)
WSB/EiJ MGP_WSBEiJ_G0022906
 protein coding gene Chr17:34904687-34910554 (-)



Homology
more
  • Human Ortholog
    CSNK2B, casein kinase 2 beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSNK2B, casein kinase 2 beta
  • Synonyms
    CK2B, CK2N, Ckb1, Ckb2, CSK2B, G5A, POBINDS
  • Links
    NCBI Gene ID: 1460
    neXtProt AC: NX_P67870
    UniProt: P67870

  • Chr Location
    6p21.33; chr6:31665227-31670343 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit embryonic lethality post-implantation, growth retardation and arrest, a failure to form an inner cell mass and smaller size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    79
  • cDNA Data
    196
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024387 Ensembl Gene Model | MGI Sequence Detail 5858 C57BL/6J ±  kb
    transcript ENSMUST00000174024 Ensembl | MGI Sequence Detail 883 Not Applicable  
    polypeptide ENSMUSP00000134673 Ensembl | MGI Sequence Detail 257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000005952 casein kinase II subunit beta
      (term hierarchy)
    • InterPro Domains
      IPR000704 Casein kinase II, regulatory subunit
      IPR016149 Casein kinase II, regulatory subunit, N-terminal
      IPR035991 Casein kinase II subunit beta-like
    • GlyGen
      P67871 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 207
      Genomic 9
      cDNA 196
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2206
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 12
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:10587 Kopatz I, et al., The nucleotide sequence of the mouse cDNA encoding the beta subunit of casein kinase II. Nucleic Acids Res. 1990 Jun 25;18(12):3639
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory