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Serpina1d Gene Detail
Summary
  • Symbol
    Serpina1d
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1D
  • Synonyms
    PI4, Spi1-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:891968
    NCBI Gene: 20703
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103729853-103739851 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 52.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891968
 protein coding gene Chr12:103729846-103739892 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020060
 protein coding gene Chr12:105685365-105696153 (-)
A/J MGP_AJ_G0020014
 protein coding gene Chr12:101440157-101450793 (-)
AKR/J MGP_AKRJ_G0019992
 protein coding gene Chr12:104455916-104482256 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0019806
 protein coding gene Chr12:104912029-104923480 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0018063
 protein coding gene Chr12:98377689-98387712 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0019888
 protein coding gene Chr12:101079002-101081766 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0019962
 protein coding gene Chr12:105331486-105336319 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018909
 protein coding gene Chr12:98178567-98191047 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SERPINA1, serpin family A member 1
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA1, serpin family A member 1
  • Synonyms
    A1A, A1AT, AAT, alpha1AT, nNIF, PI, PI1, PRO2275
  • Links
    NCBI Gene ID: 5265
    neXtProt AC: NX_P01009
    UniProt: P01009

  • Chr Location
    14q32.13; chr14:94376747-94390693 (-)  GRCh38
Human Diseases
more
  • Diseases
    9 with human SERPINA1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    6
  • cDNA Data
    4
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071177 Ensembl Gene Model | MGI Sequence Detail 9999 C57BL/6J ±  kb
transcript ENSMUST00000078869 Ensembl | MGI Sequence Detail 1394 Not Applicable  
polypeptide ENSMUSP00000077909 Ensembl | MGI Sequence Detail 413 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 2
    cDNA 5

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144762
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:23546 Borriello F, et al., Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9417-21
  • Latest
    J:350763 Volkert I, et al., Impact of PNPLA3 I148M on alpha-1 antitrypsin deficiency-dependent liver disease progression. Hepatology. 2024 Apr 1;79(4):898-911
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory