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Gykl1 Gene Detail
Summary
  • Symbol
    Gykl1
  • Name
    glycerol kinase-like 1
  • Synonyms
    Gk-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891990
    NCBI Gene: 14625
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:52826762-52828622 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 28.25 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891990
 protein coding gene Chr18:52826751-52828665 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024431
 protein coding gene Chr18:51821340-51823329 (+)
A/J MGP_AJ_G0024397
 protein coding gene Chr18:49830244-49832233 (+)
AKR/J MGP_AKRJ_G0024367
 protein coding gene Chr18:51218315-51220304 (+)
BALB/cJ MGP_BALBcJ_G0024397
 protein coding gene Chr18:50013260-50015249 (+)
C3H/HeJ MGP_C3HHeJ_G0024164
 protein coding gene Chr18:51352917-51354906 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024843
 protein coding gene Chr18:53580199-53582188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022275
 protein coding gene Chr18:49618271-49620261 (+)
CAST/EiJ MGP_CASTEiJ_G0023638
 protein coding gene Chr18:51318865-51320854 (+)
CBA/J MGP_CBAJ_G0024134
 protein coding gene Chr18:55147140-55149129 (+)
DBA/2J MGP_DBA2J_G0024264
 protein coding gene Chr18:49535482-49537471 (+)
FVB/NJ MGP_FVBNJ_G0024231
 protein coding gene Chr18:48961353-48963342 (+)
LP/J MGP_LPJ_G0024349
 protein coding gene Chr18:51854466-51856455 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024261
 protein coding gene Chr18:56905917-56907906 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024890
 protein coding gene Chr18:51233515-51235504 (+)
PWK/PhJ MGP_PWKPhJ_G0023382
 protein coding gene Chr18:49532439-49534428 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023188
 protein coding gene Chr18:51414319-51416308 (+)
WSB/EiJ MGP_WSBEiJ_G0023701
 protein coding gene Chr18:51150005-51151994 (+)



Homology
more
  • Human Ortholog
    GK, glycerol kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GK, glycerol kinase
  • Synonyms
    GK1, GKD
  • Links
    NCBI Gene ID: 2710
    neXtProt AC: NX_P32189
    UniProt: P32189

  • Chr Location
    Xp21.2; chrX:30653359-30731462 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GK associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The gene product is involved in mitochondrial dynamics in sperm cells. Homozygous KO causes sperm motility defects which leads to male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053624 Ensembl Gene Model | MGI Sequence Detail 1861 C57BL/6J ±  kb
    transcript ENSMUST00000066193 Ensembl | MGI Sequence Detail 1861 Not Applicable  
    polypeptide ENSMUSP00000067598 Ensembl | MGI Sequence Detail 549 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 25

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147227
    References
    more
    • Summaries
      All 30
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:40192 Dixon J, et al., Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1. Hum Mol Genet. 1997 May;6(5):727-37
    • Latest
      J:327181 Lewis MA, et al., Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. BMC Biol. 2022 Mar 17;20(1):67
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory