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Plscr1 Gene Detail
Summary
  • Symbol
    Plscr1
  • Name
    phospholipid scramblase 1
  • Synonyms
    MmTRA1a, MmTRA1b, MuPLSCR2, NOR1, TRA1, Tras1, Tras2
  • Feature Type
    protein coding gene
  • IDs
    MGI:893575
    NCBI Gene: 22038
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:92132265-92154034 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 48.35 cM, cytoband E3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    892 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_893575
 protein coding gene Chr9:92131803-92154331 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035126
 protein coding gene Chr9:93299452-93321551 (+)
A/J MGP_AJ_G0035107
 protein coding gene Chr9:90070627-90093867 (+)
AKR/J MGP_AKRJ_G0035039
 protein coding gene Chr9:92174299-92187875 (+)
BALB/cJ MGP_BALBcJ_G0035100
 protein coding gene Chr9:89719801-89742485 (+)
C3H/HeJ MGP_C3HHeJ_G0034810
 protein coding gene Chr9:92639545-92660421 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035620
 protein coding gene Chr9:95904479-95930743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032523
 protein coding gene Chr9:88079600-88102599 (+)
CAST/EiJ MGP_CASTEiJ_G0034122
 protein coding gene Chr9:92375318-92399615 (+)
CBA/J MGP_CBAJ_G0034778
 protein coding gene Chr9:99246347-99261850 (+)
DBA/2J MGP_DBA2J_G0034940
 protein coding gene Chr9:89588556-89611105 (+)
FVB/NJ MGP_FVBNJ_G0034888
 protein coding gene Chr9:88553030-88575568 (+)
LP/J MGP_LPJ_G0035019
 protein coding gene Chr9:93489606-93518030 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034927
 protein coding gene Chr9:101164854-101201256 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035640
 protein coding gene Chr9:92449168-92471481 (+)
PWK/PhJ MGP_PWKPhJ_G0033829
 protein coding gene Chr9:89744214-89767880 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033664
 protein coding gene Chr9:92494603-92515982 (+)
WSB/EiJ MGP_WSBEiJ_G0034242
 protein coding gene Chr9:92324849-92347591 (+)



Homology
more
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Synonyms
    MMTRA1B
  • Links
    NCBI Gene ID: 5359
    neXtProt AC: NX_O15162
    UniProt: O15162

  • Chr Location
    3q24; chr3:146515180-146544856 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a grossly normal phenotype although there are hematopoietic abnormalities in newborn mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    4
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22038 NCBI Gene Model | MGI Sequence Detail 21770 C57BL/6J ±  kb
    transcript NM_001410453 RefSeq | MGI Sequence Detail 1607 C57BL/6  
    polypeptide Q9JJ00 UniProt | EBI | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:893574
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:39827 Kasukabe T, et al., TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines. Blood. 1997 Apr 15;89(8):2975-85
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory