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Stx4a Gene Detail
Summary
  • Symbol
    Stx4a
  • Name
    syntaxin 4A (placental)
  • Synonyms
    Stx4, Syn-4, Syn4
  • Feature Type
    protein coding gene
  • IDs
    MGI:893577
    NCBI Gene: 20909
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127439832-127450160 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.77 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_893577
 protein coding gene Chr7:127423466-127450160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033057
 protein coding gene Chr7:132199010-132228291 (+)
A/J MGP_AJ_G0033040
 protein coding gene Chr7:128665082-128693592 (+)
AKR/J MGP_AKRJ_G0032972
 protein coding gene Chr7:131992330-132020475 (+)
BALB/cJ MGP_BALBcJ_G0033041
 protein coding gene Chr7:128317960-128343671 (+)
C3H/HeJ MGP_C3HHeJ_G0032755
 protein coding gene Chr7:131892589-131921867 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033550
 protein coding gene Chr7:137349312-137379791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030523
 protein coding gene Chr7:129863718-129885937 (+)
CAST/EiJ MGP_CASTEiJ_G0032084
 protein coding gene Chr7:123690100-123713652 (+)
CBA/J MGP_CBAJ_G0032728
 protein coding gene Chr7:142005875-142040608 (+)
DBA/2J MGP_DBA2J_G0032880
 protein coding gene Chr7:126645679-126669389 (+)
FVB/NJ MGP_FVBNJ_G0032833
 protein coding gene Chr7:126504244-126530587 (+)
LP/J MGP_LPJ_G0032974
 protein coding gene Chr7:133672541-133702514 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032865
 protein coding gene Chr7:143085290-143112783 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033570
 protein coding gene Chr7:130984963-131009925 (+)
PWK/PhJ MGP_PWKPhJ_G0031791
 protein coding gene Chr7:119658168-119682313 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031637
 protein coding gene Chr7:117787162-117812736 (+)
WSB/EiJ MGP_WSBEiJ_G0032196
 protein coding gene Chr7:131952171-131978124 (+)



Homology
more
  • Human Ortholog
    STX4, syntaxin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STX4, syntaxin 4
  • Synonyms
    DFNB123, p35-2, STX4A
  • Links
    NCBI Gene ID: 6810
    neXtProt AC: NX_Q12846
    UniProt: Q12846

  • Chr Location
    16p11.2; chr16:31032889-31042975 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STX4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele die in early embyonic stages. Heterozygous mice exhibit abnormalities in glucose metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    119
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    33
  • cDNA Data
    52
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20909 NCBI Gene Model | MGI Sequence Detail 10329 C57BL/6J ±  kb
    transcript NM_001417272 RefSeq | MGI Sequence Detail 1478 C57BL/6  
    polypeptide P70452 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 54

      Microarray probesets 3
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 5
      Gene Ontology 27
      Phenotypes 15
    • Earliest
      J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
    • Latest
      J:348947 Yu X, et al., Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway. Nat Commun. 2024 Apr 2;15(1):2856
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory