About   Help   FAQ
Rab21 Gene Detail
Summary
  • Symbol
    Rab21
  • Name
    RAB21, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:894308
    NCBI Gene: 216344
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:115125767-115151540 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 63.51 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    873 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894308
 protein coding gene Chr10:115122989-115151540 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017735
 protein coding gene Chr10:117987903-118013630 (-)
A/J MGP_AJ_G0017711
 protein coding gene Chr10:113461583-113487203 (-)
AKR/J MGP_AKRJ_G0017673
 protein coding gene Chr10:116756066-116781801 (-)
BALB/cJ MGP_BALBcJ_G0017674
 protein coding gene Chr10:113858076-113884100 (-)
C3H/HeJ MGP_C3HHeJ_G0017499
 protein coding gene Chr10:116977223-117004358 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018131
 protein coding gene Chr10:122089656-122117931 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015811
 protein coding gene Chr10:108092121-108116657 (-)
CAST/EiJ MGP_CASTEiJ_G0017061
 protein coding gene Chr10:117199707-117227896 (-)
CBA/J MGP_CBAJ_G0017468
 protein coding gene Chr10:126849860-126877820 (-)
DBA/2J MGP_DBA2J_G0017573
 protein coding gene Chr10:112613414-112639835 (-)
FVB/NJ MGP_FVBNJ_G0017568
 protein coding gene Chr10:111563007-111588728 (-)
LP/J MGP_LPJ_G0017648
 protein coding gene Chr10:118574657-118600385 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017597
 protein coding gene Chr10:129808459-129834182 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018169
 protein coding gene Chr10:116781004-116808132 (-)
PWK/PhJ MGP_PWKPhJ_G0016843
 protein coding gene Chr10:112680486-112706264 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016633
 protein coding gene Chr10:115588614-115615942 (-)
WSB/EiJ MGP_WSBEiJ_G0017121
 protein coding gene Chr10:116957885-116985621 (-)



Homology
more
  • Human Ortholog
    RAB21, RAB21, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB21, RAB21, member RAS oncogene family
  • Links
    NCBI Gene ID: 23011
    neXtProt AC: NX_Q9UL25
    UniProt: Q9UL25

  • Chr Location
    12q21.1; chr12:71754863-71800286 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in chorion formation and placentation, abnormal trophoblast layer morphology, and complete lethality throughout fetal growth and development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    10
  • cDNA Data
    78
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216344 NCBI Gene Model | MGI Sequence Detail 25774 C57BL/6J ±  kb
    transcript NM_024454 RefSeq | MGI Sequence Detail 1856 Not Specified  
    polypeptide P35282 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 2
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory