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Mknk1 Gene Detail
Summary
  • Symbol
    Mknk1
  • Name
    MAP kinase-interacting serine/threonine kinase 1
  • Synonyms
    2410048M24Rik, Mnk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:894316
    NCBI Gene: 17346
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115696395-115736447 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    792 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894316
 protein coding gene Chr4:115695140-115736453 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028610
 protein coding gene Chr4:116682690-116723538 (+)
A/J MGP_AJ_G0028571
 protein coding gene Chr4:112229329-112269367 (+)
AKR/J MGP_AKRJ_G0028520
 protein coding gene Chr4:114635568-114675780 (+)
BALB/cJ MGP_BALBcJ_G0028592
 protein coding gene Chr4:112857748-112897790 (+)
C3H/HeJ MGP_C3HHeJ_G0028306
 protein coding gene Chr4:116214536-116255036 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029033
 protein coding gene Chr4:121206853-121248017 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026317
 protein coding gene Chr4:106276294-106315608 (+)
CAST/EiJ MGP_CASTEiJ_G0027740
 protein coding gene Chr4:113416228-113462561 (+)
CBA/J MGP_CBAJ_G0028273
 protein coding gene Chr4:124498613-124541368 (+)
DBA/2J MGP_DBA2J_G0028421
 protein coding gene Chr4:112878610-112918576 (+)
FVB/NJ MGP_FVBNJ_G0028389
 protein coding gene Chr4:111363969-111404731 (+)
LP/J MGP_LPJ_G0028523
 protein coding gene Chr4:116900722-116940822 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028416
 protein coding gene Chr4:129518264-129560586 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029070
 protein coding gene Chr4:115793119-115833342 (+)
PWK/PhJ MGP_PWKPhJ_G0027466
 protein coding gene Chr4:109638145-109677356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027289
 protein coding gene Chr4:112034622-112077868 (+)
WSB/EiJ MGP_WSBEiJ_G0027819
 protein coding gene Chr4:115656304-115699379 (+)



Homology
more
  • Human Ortholog
    MKNK1, MAPK interacting serine/threonine kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MKNK1, MAPK interacting serine/threonine kinase 1
  • Synonyms
    MNK1
  • Links
    NCBI Gene ID: 8569
    neXtProt AC: NX_Q9BUB5
    UniProt: Q9BUB5

  • Chr Location
    1p33; chr1:46557407-46616843 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    31 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Mknk1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    26 strains or lines available
Homozygous null mice are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    45
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1054
  • Tissues
    169
  • cDNA Data
    61
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028708 Ensembl Gene Model | MGI Sequence Detail 40053 C57BL/6J ±  kb
transcript ENSMUST00000019677 Ensembl | MGI Sequence Detail 2543 Not Applicable  
polypeptide ENSMUSP00000019677 Ensembl | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 63
    cDNA 62
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1920925
References
more
  • Summaries
    All 67
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 31
  • Earliest
    J:40024 Waskiewicz AJ, et al., Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 1997 Apr 15;16(8):1909-20
  • Latest
    J:350887 Franco-Enzastiga U, et al., Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction. iScience. 2024 Feb 16;27(2):108808
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory