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Tnfrsf18 Gene Detail
Summary
  • Symbol
    Tnfrsf18
  • Name
    tumor necrosis factor receptor superfamily, member 18
  • Synonyms
    Gitr
  • Feature Type
    protein coding gene
  • IDs
    MGI:894675
    NCBI Gene: 21936
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:156110779-156113351 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 87.76 cM, cytoband E
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894675
 protein coding gene Chr4:156110621-156113352 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029244
 protein coding gene Chr4:160395701-160398428 (+)
A/J MGP_AJ_G0029209
 protein coding gene Chr4:153635869-153638596 (+)
AKR/J MGP_AKRJ_G0029157
 protein coding gene Chr4:157816582-157819309 (+)
BALB/cJ MGP_BALBcJ_G0029225
 protein coding gene Chr4:154111610-154114337 (+)
C3H/HeJ MGP_C3HHeJ_G0028946
 protein coding gene Chr4:158379674-158382401 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029674
 protein coding gene Chr4:166079500-166082231 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026918
 protein coding gene Chr4:145915619-145918325 (+)
CAST/EiJ MGP_CASTEiJ_G0028358
 protein coding gene Chr4:155819127-155821849 (+)
CBA/J MGP_CBAJ_G0028908
 protein coding gene Chr4:171119712-171122439 (+)
DBA/2J MGP_DBA2J_G0029057
 protein coding gene Chr4:153658872-153661599 (+)
FVB/NJ MGP_FVBNJ_G0029020
 protein coding gene Chr4:152906436-152909167 (+)
LP/J MGP_LPJ_G0029147
 protein coding gene Chr4:160335891-160338618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029047
 protein coding gene Chr4:173913883-173916614 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029706
 protein coding gene Chr4:158463493-158466220 (+)
PWK/PhJ MGP_PWKPhJ_G0028079
 protein coding gene Chr4:149799008-149801571 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027913
 protein coding gene Chr4:152710602-152713328 (+)
WSB/EiJ MGP_WSBEiJ_G0028438
 protein coding gene Chr4:158625975-158628706 (+)



Homology
more
  • Human Ortholog
    TNFRSF18, TNF receptor superfamily member 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF18, TNF receptor superfamily member 18
  • Synonyms
    AITR, CD357, ENERGEN, GITR, GITR-D
  • Links
    NCBI Gene ID: 8784
    neXtProt AC: NX_Q9Y5U5
    UniProt: Q9Y5U5

  • Chr Location
    1p36.33; chr1:1203508-1206592 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display dysregulation of T-cell receptor/CD3-driven T-cell activation and programmed cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    36
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21936 NCBI Gene Model | MGI Sequence Detail 2573 C57BL/6J ±  kb
    transcript NM_009400 RefSeq | MGI Sequence Detail 1030 C57BL/6  
    polypeptide O35714 UniProt | EBI | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 47
    • Earliest
      J:40999 Nocentini G, et al., A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6216-21
    • Latest
      J:352340 Wang X, et al., Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury. JCI Insight. 2024 Mar 8;9(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory