About   Help   FAQ
Dcaf8 Gene Detail
Summary
  • Symbol
    Dcaf8
  • Name
    DDB1 and CUL4 associated factor 8
  • Synonyms
    D1Dau35e, D1Ucla4, H326, Wdr42a
  • Feature Type
    protein coding gene
  • IDs
    MGI:91860
    NCBI Gene: 98193
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171975574-172023959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1038 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_91860
 protein coding gene Chr1:171975574-172024572 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016779
 protein coding gene Chr1:178002331-178054816 (+)
A/J MGP_AJ_G0016758
 protein coding gene Chr1:170714816-170765262 (+)
AKR/J MGP_AKRJ_G0016724
 protein coding gene Chr1:175875064-175927493 (+)
BALB/cJ MGP_BALBcJ_G0016719
 protein coding gene Chr1:171262824-171312017 (+)
C3H/HeJ MGP_C3HHeJ_G0016543
 protein coding gene Chr1:176450989-176500096 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017181
 protein coding gene Chr1:183907297-183962904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014887
 protein coding gene Chr1:162421199-162470178 (+)
CAST/EiJ MGP_CASTEiJ_G0016123
 protein coding gene Chr1:175809682-175860345 (+)
CBA/J MGP_CBAJ_G0016517
 protein coding gene Chr1:190456380-190516160 (+)
DBA/2J MGP_DBA2J_G0016624
 protein coding gene Chr1:169655004-169702124 (+)
FVB/NJ MGP_FVBNJ_G0016621
 protein coding gene Chr1:167909965-167958261 (+)
LP/J MGP_LPJ_G0016695
 protein coding gene Chr1:179092885-179146530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016648
 protein coding gene Chr1:197709617-197762130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017217
 protein coding gene Chr1:175742849-175795000 (+)
PWK/PhJ MGP_PWKPhJ_G0015909
 protein coding gene Chr1:169027036-169077120 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015691
 protein coding gene Chr1:174687959-174745792 (+)
WSB/EiJ MGP_WSBEiJ_G0016185
 protein coding gene Chr1:175894957-175950215 (+)



Homology
more
  • Human Ortholog
    DCAF8, DDB1 and CUL4 associated factor 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCAF8, DDB1 and CUL4 associated factor 8
  • Synonyms
    GAN2, H326, WDR42A
  • Links
    NCBI Gene ID: 50717
    neXtProt AC: NX_Q5TAQ9
    UniProt: Q5TAQ9

  • Chr Location
    1q23.2; chr1:160215715-160262549 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DCAF8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    18
  • cDNA Data
    162
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98193 NCBI Gene Model | MGI Sequence Detail 48386 C57BL/6J ±  kb
    transcript NM_001421210 RefSeq | MGI Sequence Detail 4642 ZRU/MplStud  
    polypeptide Q8N7N5 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 196
      Genomic 25
      cDNA 166
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-5719, MGI:1347003, MGI:1888988, MGI:2138088, MGI:2138099, MGI:2138429, MGI:2138650
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory