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Drd5 Gene Detail
Summary
  • Symbol
    Drd5
  • Name
    dopamine receptor D5
  • Synonyms
    D5R, Drd1b, DRD1b, Drd-5, Gpcr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94927
    NCBI Gene: 13492
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:38476742-38479868 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 20.40 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    185 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94927
 protein coding gene Chr5:38476710-38479868 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029511
 protein coding gene Chr5:36728085-36731236 (+)
A/J MGP_AJ_G0029477
 protein coding gene Chr5:35503448-35506601 (+)
AKR/J MGP_AKRJ_G0029427
 protein coding gene Chr5:36835560-36838715 (+)
BALB/cJ MGP_BALBcJ_G0029488
 protein coding gene Chr5:35992616-35995768 (+)
C3H/HeJ MGP_C3HHeJ_G0029211
 protein coding gene Chr5:36824422-36827572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029942
 protein coding gene Chr5:38670885-38674036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027180
 protein coding gene Chr5:33176364-33179526 (+)
CAST/EiJ MGP_CASTEiJ_G0028619
 protein coding gene Chr5:35995044-35998203 (+)
CBA/J MGP_CBAJ_G0029178
 protein coding gene Chr5:39587686-39593509 (+)
DBA/2J MGP_DBA2J_G0029325
 protein coding gene Chr5:35624311-35627462 (+)
FVB/NJ MGP_FVBNJ_G0029284
 protein coding gene Chr5:35107126-35110284 (+)
LP/J MGP_LPJ_G0029411
 protein coding gene Chr5:37177893-37181044 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029314
 protein coding gene Chr5:40307057-40310208 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029975
 protein coding gene Chr5:36323406-36326552 (+)
PWK/PhJ MGP_PWKPhJ_G0028343
 protein coding gene Chr5:34791132-34794271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028177
 protein coding gene Chr5:35772689-35775836 (+)
WSB/EiJ MGP_WSBEiJ_G0028700
 protein coding gene Chr5:36403546-36406694 (+)



Homology
more
  • Human Ortholog
    DRD5, dopamine receptor D5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRD5, dopamine receptor D5
  • Synonyms
    DBDR, DRD1B, DRD1L2
  • Links
    NCBI Gene ID: 1816
    neXtProt AC: NX_P21918
    UniProt: P21918

  • Chr Location
    4p16.1; chr4:9781634-9784009 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DRD5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 5 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone. Mice homozygous for another knock-out allele exhibit increased methamphetamine-induced ambulatory activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1019
  • Tissues
    105
  • cDNA Data
    12
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13492 NCBI Gene Model | MGI Sequence Detail 3127 C57BL/6J ±  kb
    transcript NM_013503 RefSeq | MGI Sequence Detail 3127 ZRU/MplStud  
    polypeptide Q8BLD9 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 13
      Primer pair 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-16351, MGD-MRK-16359, MGD-MRK-8895, MGD-MRK-8900
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 17
      Phenotypes 53
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:331618 Li J, et al., D1/D5 Dopamine Receptors and mGluR5 Jointly Enable Non-Hebbian Long-Term Potentiation at Sensory Synapses onto Lamina I Spinoparabrachial Neurons. J Neurosci. 2022 Jan 19;42(3):350-361
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory