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En2 Gene Detail
Summary
  • Symbol
    En2
  • Name
    engrailed 2
  • Synonyms
    En-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95390
    NCBI Gene: 13799
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:28370692-28377164 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 13.94 cM
  • Mapping Data
    45 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95390
 protein coding gene Chr5:28370692-28377195 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029369
 protein coding gene Chr5:26073298-26079323 (+)
A/J MGP_AJ_G0029335
 protein coding gene Chr5:25184921-25191362 (+)
AKR/J MGP_AKRJ_G0029286
 protein coding gene Chr5:26221408-26227847 (+)
BALB/cJ MGP_BALBcJ_G0029346
 protein coding gene Chr5:25740488-25747234 (+)
C3H/HeJ MGP_C3HHeJ_G0029067
 protein coding gene Chr5:26264585-26271008 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029799
 protein coding gene Chr5:27678351-27686500 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027037
 protein coding gene Chr5:22802440-22808923 (+)
CAST/EiJ MGP_CASTEiJ_G0028478
 protein coding gene Chr5:25369277-25375590 (+)
CBA/J MGP_CBAJ_G0029035
 protein coding gene Chr5:28179341-28185785 (+)
DBA/2J MGP_DBA2J_G0029184
 protein coding gene Chr5:25407662-25414627 (+)
FVB/NJ MGP_FVBNJ_G0029142
 protein coding gene Chr5:24852318-24858677 (+)
LP/J MGP_LPJ_G0029269
 protein coding gene Chr5:26516890-26525406 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029171
 protein coding gene Chr5:29209563-29215041 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029833
 protein coding gene Chr5:25856622-25863046 (+)
PWK/PhJ MGP_PWKPhJ_G0028202
 protein coding gene Chr5:24531590-24538366 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028033
 protein coding gene Chr5:25130288-25136762 (+)
WSB/EiJ MGP_WSBEiJ_G0028558
 protein coding gene Chr5:25848886-25856166 (+)



Homology
more
  • Human Ortholog
    EN2, engrailed homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EN2, engrailed homeobox 2
  • Links
    NCBI Gene ID: 2020
    neXtProt AC: NX_P19622
    UniProt: P19622

  • Chr Location
    7q36.3; chr7:155458129-155464831 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with En2 mouse models; 1 with human EN2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 6 alleles in 9 genetic backgrounds
    45 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
This locus affects anterior-posterior cerebellar patterning. Homozygous null mutants show altered foliation pattern and perform poorly in motor learning (rotarod) tests. Heterozygotes test intermediate on rotarod. Hypomorphs show no phenotypic effects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1476
  • Tissues
    275
  • cDNA Data
    21
  • Literature Summary
    160
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039095 Ensembl Gene Model | MGI Sequence Detail 6473 C57BL/6J ±  kb
    transcript ENSMUST00000036177 Ensembl | MGI Sequence Detail 3539 Not Applicable  
    polypeptide ENSMUSP00000036761 Ensembl | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 6
      cDNA 24
      Primer pair 7
      Other 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9498, MGD-MRK-9500, MGI:2141264
    References
    more
    • Summaries
      All 312
      Developmental Gene Expression 160
      Diseases 4
      Gene Ontology 11
      Phenotypes 87
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:338083 Hwang I, et al., Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice. Mol Psychiatry. 2022 Apr;27(4):2030-2041
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory