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Fuca1 Gene Detail
Summary
  • Symbol
    Fuca1
  • Name
    fucosidase, alpha-L- 1, tissue
  • Synonyms
    0610006A03Rik, 9530055J05Rik, Afuc
  • Feature Type
    protein coding gene
  • IDs
    MGI:95593
    NCBI Gene: 71665
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135648037-135667611 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.01 cM, cytoband D3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    638 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95593
 protein coding gene Chr4:135648037-135667622 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028953
 protein coding gene Chr4:138415097-138435668 (+)
A/J MGP_AJ_G0028912
 protein coding gene Chr4:132538681-132558271 (+)
AKR/J MGP_AKRJ_G0028864
 protein coding gene Chr4:136360704-136386971 (+)
BALB/cJ MGP_BALBcJ_G0028936
 protein coding gene Chr4:133209294-133229160 (+)
C3H/HeJ MGP_C3HHeJ_G0028650
 protein coding gene Chr4:136645850-136665408 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029377
 protein coding gene Chr4:143321387-143340967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026648
 protein coding gene Chr4:125589121-125608706 (+)
CAST/EiJ MGP_CASTEiJ_G0028082
 protein coding gene Chr4:134776670-134798695 (+)
CBA/J MGP_CBAJ_G0028615
 protein coding gene Chr4:147256663-147276019 (+)
DBA/2J MGP_DBA2J_G0028764
 protein coding gene Chr4:132971419-132990893 (+)
FVB/NJ MGP_FVBNJ_G0028731
 protein coding gene Chr4:131889709-131909678 (+)
LP/J MGP_LPJ_G0028863
 protein coding gene Chr4:138514010-138534051 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028757
 protein coding gene Chr4:151539208-151558700 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029415
 protein coding gene Chr4:136820138-136839729 (+)
PWK/PhJ MGP_PWKPhJ_G0027802
 protein coding gene Chr4:129733552-129753456 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027628
 protein coding gene Chr4:132637081-132655828 (+)
WSB/EiJ MGP_WSBEiJ_G0028160
 protein coding gene Chr4:136995963-137015525 (+)



Homology
more
  • Human Ortholog
    FUCA1, alpha-L-fucosidase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUCA1, alpha-L-fucosidase 1
  • Synonyms
    FUCA
  • Links
    NCBI Gene ID: 2517
    neXtProt AC: NX_P04066
    UniProt: P04066

  • Chr Location
    1p36.11; chr1:23845077-23868290 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fuca1 mouse models; 1 with human FUCA1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Strain differences are probably due to a structural variant in Fuca1. Strains A/J, BDP, LP, P, SEA/Gn and 129/J have high FUCA activity and high heat stability; C57BL/6, C3H/He, DBA/2, BALB/c and 22 other strains have low activity and low heat stability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    95
  • cDNA Data
    136
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71665 NCBI Gene Model | MGI Sequence Detail 19575 C57BL/6J ±  kb
    transcript NM_024243 RefSeq | MGI Sequence Detail 2523 ZRU/MplStud  
    polypeptide Q99LJ1 UniProt | EBI | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      Genomic 3
      cDNA 136

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1179, MGD-MRK-9892, MGI:1918915, MGI:1925799
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:6100 Self SJ, et al., Strain variation in spermatozoal glycosidases in inbred mice. Genet Res. 1978 Oct;32(2):183-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory