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Slc6a11 Gene Detail
Summary
  • Symbol
    Slc6a11
  • Name
    solute carrier family 6 (neurotransmitter transporter, GABA), member 11
  • Synonyms
    D930045G19Rik, E130202I16Rik, Gabt4, Gat3, GAT4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95630
    NCBI Gene: 243616
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:114108202-114226847 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.98 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3814 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95630
 protein coding gene Chr6:114108202-114226913 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031139
 protein coding gene Chr6:116693515-116815948 (+)
A/J MGP_AJ_G0031108
 protein coding gene Chr6:112216320-112335021 (+)
AKR/J MGP_AKRJ_G0031039
 protein coding gene Chr6:115231124-115350797 (+)
BALB/cJ MGP_BALBcJ_G0031119
 protein coding gene Chr6:112161802-112280324 (+)
C3H/HeJ MGP_C3HHeJ_G0030589
 protein coding gene Chr6:68945626-69065978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031578
 protein coding gene Chr6:119693018-119813697 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028742
 protein coding gene Chr6:109240155-109359793 (+)
CAST/EiJ MGP_CASTEiJ_G0030226
 protein coding gene Chr6:115696928-115824898 (+)
CBA/J MGP_CBAJ_G0030805
 protein coding gene Chr6:124444867-124564815 (+)
DBA/2J MGP_DBA2J_G0030958
 protein coding gene Chr6:111292869-111410618 (+)
FVB/NJ MGP_FVBNJ_G0030912
 protein coding gene Chr6:110305065-110424929 (+)
LP/J MGP_LPJ_G0031038
 protein coding gene Chr6:116710036-116829173 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030946
 protein coding gene Chr6:128645687-128766903 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031605
 protein coding gene Chr6:115258184-115377026 (+)
PWK/PhJ MGP_PWKPhJ_G0029942
 protein coding gene Chr6:110262946-110382644 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029770
 protein coding gene Chr6:114067168-114192883 (+)
WSB/EiJ MGP_WSBEiJ_G0030310
 protein coding gene Chr6:115626597-115750579 (+)



Homology
more
  • Human Ortholog
    SLC6A11, solute carrier family 6 member 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A11, solute carrier family 6 member 11
  • Synonyms
    GAT-3, GAT3, GAT4
  • Links
    NCBI Gene ID: 6538
    neXtProt AC: NX_P48066
    UniProt: P48066

  • Chr Location
    3p25.3; chr3:10816201-10940714 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display postnatal lethality. Mice heterozygous for a targeted mutation display resistance to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1001
  • Tissues
    121
  • cDNA Data
    10
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 243616 NCBI Gene Model | MGI Sequence Detail 118646 C57BL/6J ±  kb
transcript NM_172890 RefSeq | MGI Sequence Detail 4066 ZRU/MplStud  
polypeptide P31650 UniProt | EBI | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015177 sodium- and chloride-dependent GABA transporter 3
    (term hierarchy)
  • InterPro Domains
    IPR000175 Sodium:neurotransmitter symporter
    IPR002982 Sodium:neurotransmitter symporter, GABA, GAT-3
    IPR037272 Sodium:neurotransmitter symporter superfamily
  • GlyGen
    P31650 4 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 27
    Genomic 10
    cDNA 12
    Primer pair 5

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-9950, MGI:1925977, MGI:2443874
References
more
  • Summaries
    All 54
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:3704 Liu QR, et al., Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected] [published erratum appers in J Biol Chem 1993 Apr 25;268(12):9156]. J Biol Chem. 1993 Jan 25;268(3):2106-12
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory