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Gas1 Gene Detail
Summary
  • Symbol
    Gas1
  • Name
    growth arrest specific 1
  • Synonyms
    Gas-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95655
    NCBI Gene: 14451
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:60322219-60325179 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 31.92 cM, cytoband B3-C2
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95655
 protein coding gene Chr13:60322219-60325179 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020646
 protein coding gene Chr13:59913595-59916556 (-)
A/J MGP_AJ_G0020601
 protein coding gene Chr13:57678830-57681793 (-)
AKR/J MGP_AKRJ_G0020577
 protein coding gene Chr13:59405557-59408519 (-)
BALB/cJ MGP_BALBcJ_G0020597
 protein coding gene Chr13:57937191-57940154 (-)
C3H/HeJ MGP_C3HHeJ_G0020394
 protein coding gene Chr13:59191032-59193993 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021031
 protein coding gene Chr13:61727761-61730721 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018613
 protein coding gene Chr13:55560722-55563679 (-)
CAST/EiJ MGP_CASTEiJ_G0019910
 protein coding gene Chr13:59398245-59401211 (-)
CBA/J MGP_CBAJ_G0020354
 protein coding gene Chr13:64050382-64053343 (-)
DBA/2J MGP_DBA2J_G0020478
 protein coding gene Chr13:57210700-57213661 (-)
FVB/NJ MGP_FVBNJ_G0020456
 protein coding gene Chr13:56707209-56710781 (-)
LP/J MGP_LPJ_G0020554
 protein coding gene Chr13:60181434-60184397 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020486
 protein coding gene Chr13:63333444-63336408 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021074
 protein coding gene Chr13:59005008-59007969 (-)
PWK/PhJ MGP_PWKPhJ_G0019665
 protein coding gene Chr13:57257357-57260318 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019492
 protein coding gene Chr13:57902300-57905262 (-)
WSB/EiJ MGP_WSBEiJ_G0019972
 protein coding gene Chr13:59459852-59462812 (-)



Homology
more
  • Human Ortholog
    GAS1, growth arrest specific 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAS1, growth arrest specific 1
  • Links
    NCBI Gene ID: 2619
    neXtProt AC: NX_P54826
    UniProt: P54826

  • Chr Location
    9q21.33; chr9:86944362-86947506 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    87 phenotypes from 2 alleles in 4 genetic backgrounds
    66 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene experience background sensitive reduction of viability. Developmental defects are found in the eyes, cerebellum and limbs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1311
  • Tissues
    446
  • cDNA Data
    78
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14451 NCBI Gene Model | MGI Sequence Detail 2961 C57BL/6J ±  kb
    transcript NM_008086 RefSeq | MGI Sequence Detail 2961 ZRU/MplStud  
    polypeptide Q01721 UniProt | EBI | MGI Sequence Detail 343 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      Genomic 1
      cDNA 78
      Primer pair 4
      Other 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9985, MGD-MRK-9992, MGI:2145453
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 60
      Gene Ontology 21
      Phenotypes 33
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:351872 Kumari A, et al., Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis. PLoS One. 2024;19(6):e0294835
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory