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Gas6 Gene Detail
Summary
  • Symbol
    Gas6
  • Name
    growth arrest specific 6
  • Synonyms
    Gas-6, GAS 6, growth arrest-specific
  • Feature Type
    protein coding gene
  • IDs
    MGI:95660
    NCBI Gene: 14456
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13515374-13544490 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 6.06 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    955 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95660
 protein coding gene Chr8:13515374-13544535 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033382
 protein coding gene Chr8:10820204-10849348 (-)
A/J MGP_AJ_G0033362
 protein coding gene Chr8:10426404-10455548 (-)
AKR/J MGP_AKRJ_G0033293
 protein coding gene Chr8:10711395-10740551 (-)
BALB/cJ MGP_BALBcJ_G0033363
 protein coding gene Chr8:10555538-10584705 (-)
C3H/HeJ MGP_C3HHeJ_G0033076
 protein coding gene Chr8:10921860-10950968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033875
 protein coding gene Chr8:11190240-11221524 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030843
 protein coding gene Chr8:9921753-9950834 (-)
CAST/EiJ MGP_CASTEiJ_G0032398
 protein coding gene Chr8:10680328-10710089 (-)
CBA/J MGP_CBAJ_G0033049
 protein coding gene Chr8:11665466-11695014 (-)
DBA/2J MGP_DBA2J_G0033202
 protein coding gene Chr8:10371458-10400637 (-)
FVB/NJ MGP_FVBNJ_G0033151
 protein coding gene Chr8:10386322-10416597 (-)
LP/J MGP_LPJ_G0033296
 protein coding gene Chr8:10734860-10764535 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033185
 protein coding gene Chr8:11886000-11915175 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033892
 protein coding gene Chr8:10770235-10799393 (-)
PWK/PhJ MGP_PWKPhJ_G0032111
 protein coding gene Chr8:10426647-10460304 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031953
 protein coding gene Chr8:10660944-10691454 (-)
WSB/EiJ MGP_WSBEiJ_G0032514
 protein coding gene Chr8:10805271-10837475 (-)



Homology
more
  • Human Ortholog
    GAS6, growth arrest specific 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAS6, growth arrest specific 6
  • Synonyms
    AXLLG, AXSF
  • Links
    NCBI Gene ID: 2621
    neXtProt AC: NX_Q14393
    UniProt: Q14393

  • Chr Location
    13q34; chr13:113820549-113864076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are protected against arterial and venous thrombosis, and though platelet aggregation is impaired, spontaneous or excess trauma-induced bleeding is not observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    133
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1016
  • Tissues
    92
  • cDNA Data
    150
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031451 Ensembl Gene Model | MGI Sequence Detail 29117 C57BL/6J ±  kb
    transcript ENSMUST00000033828 Ensembl | MGI Sequence Detail 2548 Not Applicable  
    polypeptide ENSMUSP00000033828 Ensembl | MGI Sequence Detail 674 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007853 growth arrest-specific protein 6
      (term hierarchy)
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR026823 Complement Clr-like EGF domain
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR051145 Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001791 Laminin G domain
    • GlyGen
      Q61592 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 151
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9991, MGD-MRK-9997
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 15
      Gene Ontology 16
      Phenotypes 46
    • Earliest
      J:9302 Schneider C, et al., Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988 Sep 9;54(6):787-93
    • Latest
      J:350238 Parinot C, et al., Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic Activity Required for Circadian Retinal Phagocytosis. Int J Mol Sci. 2024 Jun 16;25(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory