About   Help   FAQ
Gdf3 Gene Detail
Summary
  • Symbol
    Gdf3
  • Name
    growth differentiation factor 3
  • Synonyms
    ecat9, Gdf-3, Vgr-2, Vgr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95686
    NCBI Gene: 14562
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122582362-122587046 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.70 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95686
 protein coding gene Chr6:122582362-122587046 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031230
 protein coding gene Chr6:125704862-125709540 (-)
A/J MGP_AJ_G0031199
 protein coding gene Chr6:120946287-120950965 (-)
AKR/J MGP_AKRJ_G0031128
 protein coding gene Chr6:124291373-124296051 (-)
BALB/cJ MGP_BALBcJ_G0031208
 protein coding gene Chr6:120635738-120640416 (-)
C3H/HeJ MGP_C3HHeJ_G0030927
 protein coding gene Chr6:124239372-124244038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031667
 protein coding gene Chr6:129004909-129009591 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028826
 protein coding gene Chr6:117564254-117566065 (-)
CAST/EiJ MGP_CASTEiJ_G0030317
 protein coding gene Chr6:124506839-124511614 (-)
CBA/J MGP_CBAJ_G0030891
 protein coding gene Chr6:134037152-134041830 (-)
DBA/2J MGP_DBA2J_G0031047
 protein coding gene Chr6:119864303-119868991 (-)
FVB/NJ MGP_FVBNJ_G0030999
 protein coding gene Chr6:118810102-118814768 (-)
LP/J MGP_LPJ_G0031127
 protein coding gene Chr6:125857740-125862418 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031034
 protein coding gene Chr6:138008152-138012388 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031697
 protein coding gene Chr6:124187206-124191890 (-)
PWK/PhJ MGP_PWKPhJ_G0030031
 protein coding gene Chr6:118708100-118713246 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029858
 protein coding gene Chr6:122314846-122319869 (-)
WSB/EiJ MGP_WSBEiJ_G0030399
 protein coding gene Chr6:124492875-124497547 (-)



Homology
more
  • Human Ortholog
    GDF3, growth differentiation factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDF3, growth differentiation factor 3
  • Synonyms
    KFS3, MCOP7, MCOPCB6
  • Links
    NCBI Gene ID: 9573
    neXtProt AC: NX_Q9NR23
    UniProt: Q9NR23

  • Chr Location
    12p13.31; chr12:7689784-7695775 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GDF3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit prenatal lethality and resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    43
  • cDNA Data
    24
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14562 NCBI Gene Model | MGI Sequence Detail 4685 C57BL/6J ±  kb
    transcript NM_008108 RefSeq | MGI Sequence Detail 2125 ZRU/MplStud  
    polypeptide Q07104 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 24
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10034, MGD-MRK-10039, MGD-MRK-15389, MGD-MRK-15391, MGI:2141745
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 17
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:3327 Jones CM, et al., Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. Mol Endocrinol. 1992 Nov;6(11):1961-8
    • Latest
      J:326354 Allegre N, et al., NANOG initiates epiblast fate through the coordination of pluripotency genes expression. Nat Commun. 2022 Jun 21;13(1):3550
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory