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Ggt1 Gene Detail
Summary
  • Symbol
    Ggt1
  • Name
    gamma-glutamyltransferase 1
  • Synonyms
    CD224, dwg, GGT, Ggtp
  • Feature Type
    protein coding gene
  • IDs
    MGI:95706
    NCBI Gene: 14598
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75397438-75422034 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.55 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    591 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95706
 protein coding gene Chr10:75396910-75422034 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017358
 protein coding gene Chr10:75735833-75760915 (+)
A/J MGP_AJ_G0017335
 protein coding gene Chr10:73138961-73163580 (+)
AKR/J MGP_AKRJ_G0017296
 protein coding gene Chr10:75101751-75126387 (+)
BALB/cJ MGP_BALBcJ_G0017295
 protein coding gene Chr10:73333733-73358613 (+)
C3H/HeJ MGP_C3HHeJ_G0017119
 protein coding gene Chr10:75139075-75163668 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017753
 protein coding gene Chr10:78422955-78447534 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015443
 protein coding gene Chr10:69598093-69623125 (+)
CAST/EiJ MGP_CASTEiJ_G0016690
 protein coding gene Chr10:75455159-75481873 (+)
CBA/J MGP_CBAJ_G0017091
 protein coding gene Chr10:81490328-81514948 (+)
DBA/2J MGP_DBA2J_G0017196
 protein coding gene Chr10:72441791-72466599 (+)
FVB/NJ MGP_FVBNJ_G0017189
 protein coding gene Chr10:71578240-71606303 (+)
LP/J MGP_LPJ_G0017269
 protein coding gene Chr10:76230482-76256998 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017217
 protein coding gene Chr10:83589382-83613963 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017792
 protein coding gene Chr10:75124995-75152167 (+)
PWK/PhJ MGP_PWKPhJ_G0016473
 protein coding gene Chr10:72263289-72288801 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016256
 protein coding gene Chr10:74371576-74399161 (+)
WSB/EiJ MGP_WSBEiJ_G0016753
 protein coding gene Chr10:75098397-75122935 (+)



Homology
more
  • Human Ortholog
    GGT1, gamma-glutamyltransferase 1
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GGT1, gamma-glutamyltransferase 1
  • Synonyms
    CD224, D22S672, D22S732, GGT, GGT 1, GGTD, GTG
  • Links
    NCBI Gene ID: 2678
    neXtProt AC: NX_P19440
    UniProt: P19440

  • Chr Location
    22q11.23; chr22:24583750-24629005 (+)  GRCh38
  • Human Ortholog
    GGT2P, gamma-glutamyltransferase 2, pseudogene
  • Synonyms
    GGT, GGT 2, GGT2
  • Links
    NCBI Gene ID: 728441
    UniProt: P36268

  • Chr Location
    22q11.21; chr22:21207973-21259684 (-)  GRCh38
  • Human Ortholog
    GGT3P, gamma-glutamyltransferase 3 pseudogene
  • Synonyms
    GGT3
  • Links
    NCBI Gene ID: 2679
    UniProt: A6NGU5

  • Chr Location
    22q11.21; chr22:18773689-18791961 (-)  GRCh38
  • Human Ortholog
    GGTLC1, gamma-glutamyltransferase light chain 1
  • Synonyms
    dJ831C21.1, dJ831C21.2, GGTL6, GGTLA3, GGTLA4
  • Links
    NCBI Gene ID: 92086
    neXtProt AC: NX_Q9BX51
    UniProt: Q9BX51

  • Chr Location
    20p11.21; chr20:23985050-23988779 (-)  GRCh38
  • Human Ortholog
    GGTLC2, gamma-glutamyltransferase light chain 2
  • Synonyms
    GGTL4
  • Links
    NCBI Gene ID: 91227
    neXtProt AC: NX_Q14390
    UniProt: Q14390

  • Chr Location
    22q11.22; chr22:22644614-22647898 (+)  GRCh38
  • Human Ortholog
    GGTLC3, gamma-glutamyltransferase light chain family member 3
  • Synonyms
    GGT
  • Links
    NCBI Gene ID: 728226
    UniProt: B5MD39

  • Chr Location
    22q11.21; chr22:18516338-18518166 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GGT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    41
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    142
  • cDNA Data
    18
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006345 Ensembl Gene Model | MGI Sequence Detail 24597 C57BL/6J ±  kb
    transcript ENSMUST00000006508 Ensembl | MGI Sequence Detail 2167 Not Applicable  
    polypeptide ENSMUSP00000006508 Ensembl | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 6
      cDNA 19
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 14
      Gene Ontology 12
      Phenotypes 40
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:336675 Yang Y, et al., m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis. Front Immunol. 2022;13:1094556
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory