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Gnrhr Gene Detail
Summary
  • Symbol
    Gnrhr
  • Name
    gonadotropin releasing hormone receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:95790
    NCBI Gene: 14715
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:86328613-86345760 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    727 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95790
 protein coding gene Chr5:86328613-86345760 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029666
 protein coding gene Chr5:87014982-87036139 (-)
A/J MGP_AJ_G0029634
 protein coding gene Chr5:83454221-83470899 (-)
AKR/J MGP_AKRJ_G0029582
 protein coding gene Chr5:86227587-86244233 (-)
BALB/cJ MGP_BALBcJ_G0029643
 protein coding gene Chr5:84360709-84377846 (-)
C3H/HeJ MGP_C3HHeJ_G0029366
 protein coding gene Chr5:86711138-86727943 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030097
 protein coding gene Chr5:90603401-90622194 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027339
 protein coding gene Chr5:79318439-79335300 (-)
CAST/EiJ MGP_CASTEiJ_G0028774
 protein coding gene Chr5:85982785-86003696 (-)
CBA/J MGP_CBAJ_G0029335
 protein coding gene Chr5:93507209-93527697 (-)
DBA/2J MGP_DBA2J_G0029480
 protein coding gene Chr5:83627340-83650726 (-)
FVB/NJ MGP_FVBNJ_G0029441
 protein coding gene Chr5:82585883-82603098 (-)
LP/J MGP_LPJ_G0029567
 protein coding gene Chr5:87426157-87447327 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029469
 protein coding gene Chr5:98357286-98382732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030130
 protein coding gene Chr5:85811653-85829726 (-)
PWK/PhJ MGP_PWKPhJ_G0028498
 protein coding gene Chr5:82614293-82631224 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028332
 protein coding gene Chr5:85164531-85183828 (-)
WSB/EiJ MGP_WSBEiJ_G0028855
 protein coding gene Chr5:86152712-86174922 (-)



Homology
more
  • Human Ortholog
    GNRHR, gonadotropin releasing hormone receptor
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNRHR, gonadotropin releasing hormone receptor
  • Synonyms
    GNRHR1, GRHR, HH7, LHRHR, LRHR
  • Links
    NCBI Gene ID: 2798
    neXtProt AC: NX_P30968
    UniProt: P30968

  • Chr Location
    4q13.2; chr4:67737118-67754388 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gnrhr mouse models; 1 with human GNRHR associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 5 alleles in 5 genetic backgrounds
    47 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display prepubescent internal reproductive tracts with hypogonadism and hypogonadotrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    11
  • cDNA Data
    14
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14715 NCBI Gene Model | MGI Sequence Detail 17148 C57BL/6J ±  kb
    transcript NM_010323 RefSeq | MGI Sequence Detail 2482 ZRU/MplStud  
    polypeptide Q01776 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 16
      cDNA 15
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10209
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 6
      Phenotypes 55
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:350735 Farkas I, et al., Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice. Front Endocrinol (Lausanne). 2024;15:1353151
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory