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Grik3 Gene Detail
Summary
  • Symbol
    Grik3
  • Name
    glutamate receptor, ionotropic, kainate 3
  • Synonyms
    Glur-7, Glur7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95816
    NCBI Gene: 14807
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:125384493-125607966 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 58.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6888 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95816
 protein coding gene Chr4:125384025-125607966 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028766
 protein coding gene Chr4:127097131-127323691 (+)
A/J MGP_AJ_G0028725
 protein coding gene Chr4:122099176-122321340 (+)
AKR/J MGP_AKRJ_G0028678
 protein coding gene Chr4:125452841-125682956 (+)
BALB/cJ MGP_BALBcJ_G0028748
 protein coding gene Chr4:122690793-122909237 (+)
C3H/HeJ MGP_C3HHeJ_G0028462
 protein coding gene Chr4:125523414-125747162 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029190
 protein coding gene Chr4:131978708-132218524 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026463
 protein coding gene Chr4:115263796-115483331 (+)
CAST/EiJ MGP_CASTEiJ_G0027895
 protein coding gene Chr4:123616678-123846928 (+)
CBA/J MGP_CBAJ_G0028428
 protein coding gene Chr4:135237955-135462346 (+)
DBA/2J MGP_DBA2J_G0028577
 protein coding gene Chr4:122572365-122793243 (+)
FVB/NJ MGP_FVBNJ_G0028544
 protein coding gene Chr4:121207820-121429220 (+)
LP/J MGP_LPJ_G0028678
 protein coding gene Chr4:127385510-127613993 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028570
 protein coding gene Chr4:140223648-140447079 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029228
 protein coding gene Chr4:125803226-126033814 (+)
PWK/PhJ MGP_PWKPhJ_G0027616
 protein coding gene Chr4:119015165-119238946 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027442
 protein coding gene Chr4:121600930-121831258 (+)
WSB/EiJ MGP_WSBEiJ_G0027975
 protein coding gene Chr4:125897726-126126272 (+)



Homology
more
  • Human Ortholog
    GRIK3, glutamate ionotropic receptor kainate type subunit 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIK3, glutamate ionotropic receptor kainate type subunit 3
  • Synonyms
    EAA5, GLR7, GluK3, GLUR7, GluR7a
  • Links
    NCBI Gene ID: 2899
    neXtProt AC: NX_Q13003
    UniProt: Q13003

  • Chr Location
    1p34.3; chr1:36795527-37034515 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit significantly reduced short- and long-term synaptic potentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    43
  • cDNA Data
    19
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001985 Ensembl Gene Model | MGI Sequence Detail 223474 C57BL/6J ±  kb
    transcript ENSMUST00000030676 Ensembl | MGI Sequence Detail 8973 Not Applicable  
    polypeptide ENSMUSP00000030676 Ensembl | MGI Sequence Detail 919 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008242 glutamate receptor ionotropic, kainate 3
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      B1AS29 12 sites, 12 N-linked glycans (7 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 20
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10146, MGD-MRK-10153, MGD-MRK-10254
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 13
      Gene Ontology 12
      Phenotypes 23
    • Earliest
      J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
    • Latest
      J:353307 Ratsika A, et al., Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour. Brain Behav Immun. 2024 Jul 18;121:317-330
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory