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Gsc Gene Detail
Summary
  • Symbol
    Gsc
  • Name
    goosecoid homeobox
  • Synonyms
    goosecoid
  • Feature Type
    protein coding gene
  • IDs
    MGI:95841
    NCBI Gene: 14836
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr12:104437468-104439495 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 54.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95841
 protein coding gene Chr12:104437468-104439589 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020077
 protein coding gene Chr12:106268839-106270961 (-)
A/J MGP_AJ_G0020031
 protein coding gene Chr12:102231255-102233376 (-)
AKR/J MGP_AKRJ_G0020008
 protein coding gene Chr12:105183140-105185261 (-)
BALB/cJ MGP_BALBcJ_G0020017
 protein coding gene Chr12:102645951-102648072 (-)
C3H/HeJ MGP_C3HHeJ_G0019820
 protein coding gene Chr12:105642307-105644428 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020463
 protein coding gene Chr12:109575758-109577879 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018076
 protein coding gene Chr12:98942082-98944201 (-)
CAST/EiJ MGP_CASTEiJ_G0019361
 protein coding gene Chr12:100461207-100469675 (-)
CBA/J MGP_CBAJ_G0019787
 protein coding gene Chr12:113787597-113789718 (-)
DBA/2J MGP_DBA2J_G0019904
 protein coding gene Chr12:101780612-101782733 (-)
FVB/NJ MGP_FVBNJ_G0019889
 protein coding gene Chr12:100562464-100564586 (-)
LP/J MGP_LPJ_G0019979
 protein coding gene Chr12:106139734-106141856 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019927
 protein coding gene Chr12:117264496-117266617 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020492
 protein coding gene Chr12:104607177-104609298 (-)
PWK/PhJ MGP_PWKPhJ_G0019124
 protein coding gene Chr12:96278250-96286924 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018926
 protein coding gene Chr12:98872263-98874386 (-)
WSB/EiJ MGP_WSBEiJ_G0019420
 protein coding gene Chr12:105585253-105587375 (-)



Homology
more
  • Human Ortholog
    GSC, goosecoid homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSC, goosecoid homeobox
  • Synonyms
    GSC1, SAMS
  • Links
    NCBI Gene ID: 145258
    neXtProt AC: NX_P56915
    UniProt: P56915

  • Chr Location
    14q32.13; chr14:94768223-94770113 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 2 alleles in 5 genetic backgrounds
    39 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit craniofacial abnormalities affecting the mandible, nasal cavities and pits, tongue, and inner ear, and skeletal defects involving ribs, sternum, shoulder and hip. Mutants die neonatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1523
  • Tissues
    388
  • cDNA Data
    15
  • Literature Summary
    171
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14836 NCBI Gene Model | MGI Sequence Detail 2028 C57BL/6J ±  kb
    transcript NM_010351 RefSeq | MGI Sequence Detail 1183 ZRU/MplStud  
    polypeptide Q02591 UniProt | EBI | MGI Sequence Detail 256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 8
      cDNA 16
      Primer pair 10
      Other 26

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10283
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 171
      Gene Ontology 12
      Phenotypes 24
    • Earliest
      J:1337 Blum M, et al., Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell. 1992 Jun 26;69(7):1097-106
    • Latest
      J:347618 Qin T, et al., Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation. Cell Rep. 2024 Apr 23;43(4):114083
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory