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H2 Complex/Cluster/Region Detail
Summary
  • Symbol
    H2
  • Name
    histocompatibility-2, MHC
  • Synonyms
    H-2, MHC-II
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:95894
    NCBI Gene: 111364
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 17, cytoband B-C
  • Mapping Data
    216 experiments
Strain
Comparison
more
Human Diseases
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  • Mutations/Alleles
    5 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 9 alleles in 11 genetic backgrounds
    89 phenotypes from multigenic genotypes
    2 images
    532 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, H2-Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.
Expression
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  • cDNA Data
    5
  • Literature Summary
    4
Sequences &
Gene Models
less
Molecular
Reagents
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  • All nucleic 10
    cDNA 8
    Other 2
Other
Accession IDs
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MGD-MRK-10366, MGD-MRK-10489
References
more
  • Summaries
    All 852
    Developmental Gene Expression 4
    Diseases 7
    Phenotypes 532
  • Earliest
    J:301 Snell GD, Preliminary data on crossing-over between H-2, and Fu, Ki and T in the mouse. Heredity. 1952;6(2):247-54
  • Latest
    J:355474 Mitchell JS, et al., CD4(+) T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes. Immunity. 2024 Oct 8;57(10):2399-2415.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory