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H2-Ob Gene Detail
Summary
  • Symbol
    H2-Ob
  • Name
    histocompatibility 2, O region beta locus
  • Synonyms
    A-beta-2, A-beta2, H2-Ab, H2-Ab2, H-2I, H2-IAb2, H-2Ob, Ob, vic1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95925
    NCBI Gene: 15002
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34457879-34464882 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    33
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95925
 protein coding gene Chr17:34457877-34473388 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023566
 protein coding gene Chr17:34241211-34249719 (+)
A/J MGP_AJ_G0023528
 protein coding gene Chr17:33068673-33076883 (+)
AKR/J MGP_AKRJ_G0023493
 protein coding gene Chr17:33454798-33461870 (+)
BALB/cJ MGP_BALBcJ_G0023532
 protein coding gene Chr17:33234126-33242383 (+)
C3H/HeJ MGP_C3HHeJ_G0023292
 protein coding gene Chr17:33811576-33820918 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023972
 protein coding gene Chr17:35528840-35535828 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021451
 protein coding gene Chr17:30558433-30565705 (+)
CAST/EiJ MGP_CASTEiJ_G0022792
 protein coding gene Chr17:33907748-33915446 (+)
CBA/J MGP_CBAJ_G0023270
 protein coding gene Chr17:36981992-36991638 (+)
DBA/2J MGP_DBA2J_G0023399
 protein coding gene Chr17:32422598-32429837 (+)
FVB/NJ MGP_FVBNJ_G0023365
 protein coding gene Chr17:32283408-32290209 (+)
LP/J MGP_LPJ_G0023476
 protein coding gene Chr17:34499030-34507553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023388
 protein coding gene Chr17:35955791-35963441 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024015
 protein coding gene Chr17:33794028-33802206 (+)
PWK/PhJ MGP_PWKPhJ_G0022542
 protein coding gene Chr17:31357254-31364713 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022357
 protein coding gene Chr17:31752827-31759766 (+)
WSB/EiJ MGP_WSBEiJ_G0022853
 protein coding gene Chr17:33832779-33839801 (+)



Homology
more
  • Human Ortholog
    HLA-DOB, major histocompatibility complex, class II, DO beta
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DOB, major histocompatibility complex, class II, DO beta
  • Synonyms
    DOB, HLA_DOB
  • Links
    NCBI Gene ID: 3112
    neXtProt AC: NX_P13765
    UniProt: P13765

  • Chr Location
    6p21.32; chr6:32812763-32820466 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 5 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous loss-of-function mutations in this gene result in defective assembly of class II molecules, decreased susceptibility to viral infection, and decreased incidence of MMTV-induced mammary tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    9
  • cDNA Data
    49
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15002 NCBI Gene Model | MGI Sequence Detail 7004 C57BL/6J ±  kb
transcript NM_010389 RefSeq | MGI Sequence Detail 2670 ZRU/MplStud  
polypeptide NP_034519 RefSeq | MGI Sequence Detail 271 ZRU/MplStud  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR050160 Major Histocompatibility Complex/Immunoglobulin
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR014745 MHC class II, alpha/beta chain, N-terminal
    IPR000353 MHC class II, beta chain, N-terminal
Molecular
Reagents
less
  • All nucleic 76
    Genomic 25
    cDNA 49
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10378, MGD-MRK-10409, MGD-MRK-10491, MGD-MRK-10521, MGD-MRK-23933, MGI:3573871, MGI:894613
References
more
  • Summaries
    All 56
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:6885 Steinmetz M, et al., A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature. 1982 Nov 4;300(5887):35-42
  • Latest
    J:342263 Song N, et al., Proper development of long-lived memory CD4 T cells requires HLA-DO function. Front Immunol. 2023;14:1277609
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory