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H2-Q8 Gene Detail
Summary
  • Symbol
    H2-Q8
  • Name
    histocompatibility 2, Q region locus 8
  • Synonyms
    H-2Q8, Qa-8, Qa8
  • Feature Type
    protein coding gene
  • IDs
    MGI:95937
    NCBI Gene: 68395
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr17:35737710-35742945 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    1
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95937
 protein coding gene Chr17:35737710-35742945 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HLA-H, major histocompatibility complex, class I, H (pseudogene)
  • Vertebrate Orthologs
    18
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-H, major histocompatibility complex, class I, H (pseudogene)
  • Synonyms
    HLAHP
  • Links
    NCBI Gene ID: 3136
    UniProt: P01893

  • Chr Location
    6p22.1; chr6:29887573-29891079 (+)  GRCh38
Human Diseases
more
  • Diseases
    45 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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This locus controls a lymphocyte antigen recognized by a monoclonal antibody. It is present on T-cells of lymph node, spleen and bone marrow, but absent from thymus. Strains positive for antigen are C57BL/6, C57BL/10, C57L, 129, NZB and SJL; other strains tested were negative.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    21
  • Tissues
    8
  • cDNA Data
    1
  • Literature Summary
    3
Sequences &
Gene Models
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  • All Sequences
    19
  • RefSeq
    12
  • UniProt
    2
Representative SequencesLengthStrain/SpeciesFlank
genomic 68395 NCBI Gene Model | MGI Sequence Detail 5236 C57BL/6J ±  kb
transcript NM_001424319 RefSeq | MGI Sequence Detail 2246 C57BL/6  
polypeptide P14430 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008411 H-2 class I histocompatibility antigen, Q8 alpha chain
    (term hierarchy)
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
  • GlyGen
    P14430 2 sites
Molecular
Reagents
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  • All nucleic 28
    Genomic 21
    cDNA 1
    Primer pair 2
    Other 4

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10420, MGD-MRK-10533, MGD-MRK-13710, MGD-MRK-13716, MGD-MRK-13727, MGI:6721442
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 4
  • Earliest
    J:20104 Steinmetz M, et al., Clusters of genes encoding mouse transplantation antigens. Cell. 1982 Mar;28(3):489-98
  • Latest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory