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Hba-a2 Gene Detail
Summary
  • Symbol
    Hba-a2
  • Name
    hemoglobin alpha, adult chain 2
  • Synonyms
    alpha 2 globin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96016
    NCBI Gene: 110257
  • Member of
    Hba cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:32246489-32247298 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 18.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96016
 protein coding gene Chr11:32246489-32247310 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023398
 protein coding gene Chr17:25447654-25448436 (-)
A/J MGP_AJ_G0023357
 protein coding gene Chr17:24681901-24682683 (-)
AKR/J MGP_AKRJ_G0023323
 protein coding gene Chr17:24794852-24795634 (-)
BALB/cJ MGP_BALBcJ_G0023362
 protein coding gene Chr17:24904144-24904926 (-)
C3H/HeJ MGP_C3HHeJ_G0023122
 protein coding gene Chr17:25185887-25186669 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018529
 protein coding gene Chr11:31518681-31519490 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016182
 protein coding gene Chr11:27863533-27864340 (+)
CAST/EiJ MGP_CASTEiJ_G0022624
 protein coding gene Chr17:25108219-25109001 (-)
CBA/J MGP_CBAJ_G0023097
 protein coding gene Chr17:27457961-27458743 (-)
DBA/2J MGP_DBA2J_G0023227
 protein coding gene Chr17:24274779-24275561 (-)
FVB/NJ MGP_FVBNJ_G0023197
 protein coding gene Chr17:24037705-24038487 (-)
LP/J MGP_LPJ_G0023304
 protein coding gene Chr17:25721114-25721896 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023216
 protein coding gene Chr17:27016862-27017644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023844
 protein coding gene Chr17:25152176-25152958 (-)
PWK/PhJ MGP_PWKPhJ_G0022373
 protein coding gene Chr17:23048828-23049610 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022191
 protein coding gene Chr17:23209452-23210239 (-)
WSB/EiJ MGP_WSBEiJ_G0022687
 protein coding gene Chr17:25176321-25177104 (-)



Homology
more
  • Human Ortholog
    HBA1, hemoglobin subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HBA1, hemoglobin subunit alpha 1
  • Synonyms
    ECYT7, HBA-T3, HBH, METHBA
  • Links
    NCBI Gene ID: 3039
    neXtProt AC: NX_P69905
    UniProt: P69905

  • Chr Location
    16p13.3; chr16:176680-177522 (+)  GRCh38
  • Human Ortholog
    HBA2, hemoglobin subunit alpha 2
  • Synonyms
    ECYT7, HBA-T2, HBH
  • Links
    NCBI Gene ID: 3040
    neXtProt AC: NX_P69905
    UniProt: P69905

  • Chr Location
    16p13.3; chr16:172876-173710 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human HBA1,HBA2 associations

Human Disease Mouse Models
      
IDs
 View 7 models
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    248 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Radiation induced
    3
  • Targeted
    2
  • Genomic Mutations
    6 involving Hba-a2
  • Find Mice (IMSR)
    3 strains or lines available
Homozygotes for a targeted deletion of both adult hemoglobin-alpha genes die in late gestation with symptoms resembling human hydrops fetalis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    5
  • cDNA Data
    13
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069917 Ensembl Gene Model | MGI Sequence Detail 810 C57BL/6J ±  kb
transcript ENSMUST00000093207 Ensembl | MGI Sequence Detail 554 Not Applicable  
polypeptide ENSMUSP00000090895 Ensembl | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 28
    Genomic 5
    cDNA 15
    Primer pair 2
    Other 6

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10627
References
more
  • Summaries
    All 275
    Developmental Gene Expression 7
    Diseases 8
    Gene Ontology 3
    Phenotypes 248
  • Earliest
    J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
  • Latest
    J:355579 Kaminski TW, et al., Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease. Haematologica. 2024 May 1;109(5):1535-1550
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory