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Hbb-b2 Gene Detail
Summary
  • Symbol
    Hbb-b2
  • Name
    hemoglobin, beta adult minor chain
  • Synonyms
    beta2, beta min, beta minor globin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96022
    NCBI Gene: 15130
  • Member of
    Hbb cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 7, 54.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • PCR
    3
  • RFLP
    1
Homology
more
  • Human Ortholog
    HBB, hemoglobin subunit beta
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HBB, hemoglobin subunit beta
  • Synonyms
    beta-globin, CD113t-C, ECYT6
  • Links
    NCBI Gene ID: 3043
    neXtProt AC: NX_P68871
    UniProt: P68871

  • Chr Location
    11p15.4; chr11:5225464-5229395 (-)  GRCh38
  • Human Ortholog
    HBD, hemoglobin subunit delta
  • Synonyms
    HBK
  • Links
    NCBI Gene ID: 3045
    neXtProt AC: NX_P02042
    UniProt: P02042

  • Chr Location
    11p15.4; chr11:5232678-5243657 (-)  GRCh38
Human Diseases
more
  • Diseases
    14 with human HBB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
 View 17 models
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 7 models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from multigenic genotypes
    305 phenotype references
Homozygotes for targeted deletions of both adult hemoglobin-beta genes die perinatally. Heterozygotes are anemic with splenomegaly, elevated reticulocyte numbers, abnormal red cell morphology, and iron accumulation in liver, spleen, and kidney.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    108
  • Tissues
    20
  • cDNA Data
    4
  • Literature Summary
    29
Sequences &
Gene Models
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  • All Sequences
    17
  • RefSeq
    2
  • UniProt
    5
Representative SequencesLengthStrain/SpeciesFlank
genomic V00722 GenBank | ENA | DDBJ | MGI Sequence Detail 1830 Not Specified ±  kb
transcript NM_016956 RefSeq | MGI Sequence Detail 630 BALB/c  
polypeptide P02089 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 12
    cDNA 6
    Primer pair 13
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10634, MGI:2141859
References
more
  • Summaries
    All 373
    Developmental Gene Expression 29
    Diseases 12
    Gene Ontology 10
    Phenotypes 305
  • Earliest
    J:5902 Rougeon F, et al., Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro. Gene. 1977 May;1(3-4):229-39
  • Latest
    J:355579 Kaminski TW, et al., Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease. Haematologica. 2024 May 1;109(5):1535-1550
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory