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Hck Gene Detail
Summary
  • Symbol
    Hck
  • Name
    hemopoietic cell kinase
  • Synonyms
    Bmk, Hck-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96052
    NCBI Gene: 15162
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152950388-152993361 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1285 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96052
 protein coding gene Chr2:152950388-152993361 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026687
 protein coding gene Chr2:157715277-157763858 (+)
A/J MGP_AJ_G0026653
 protein coding gene Chr2:151410238-151453165 (+)
AKR/J MGP_AKRJ_G0026623
 protein coding gene Chr2:155834527-155878091 (+)
BALB/cJ MGP_BALBcJ_G0026662
 protein coding gene Chr2:151720249-151763362 (+)
C3H/HeJ MGP_C3HHeJ_G0026405
 protein coding gene Chr2:156204483-156248853 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027111
 protein coding gene Chr2:162286174-162334961 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024482
 protein coding gene Chr2:144993794-145036415 (+)
CAST/EiJ MGP_CASTEiJ_G0025866
 protein coding gene Chr2:156460828-156504648 (+)
CBA/J MGP_CBAJ_G0026383
 protein coding gene Chr2:168258845-168317506 (+)
DBA/2J MGP_DBA2J_G0026519
 protein coding gene Chr2:150619684-150662800 (+)
FVB/NJ MGP_FVBNJ_G0026485
 protein coding gene Chr2:149081121-149124596 (+)
LP/J MGP_LPJ_G0026623
 protein coding gene Chr2:157863008-157907836 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026506
 protein coding gene Chr2:172317445-172362646 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027167
 protein coding gene Chr2:155727264-155776248 (+)
PWK/PhJ MGP_PWKPhJ_G0025600
 protein coding gene Chr2:150150485-150194685 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025403
 protein coding gene Chr2:154566027-154610477 (+)
WSB/EiJ MGP_WSBEiJ_G0025936
 protein coding gene Chr2:156631985-156674994 (+)



Homology
more
  • Human Ortholog
    HCK, HCK proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCK, HCK proto-oncogene, Src family tyrosine kinase
  • Synonyms
    AIPCV, JTK9, p59Hck, p61Hck
  • Links
    NCBI Gene ID: 3055
    neXtProt AC: NX_P08631
    UniProt: P08631

  • Chr Location
    20q11.21; chr20:32052197-32101856 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    24 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Macrophages from mice homozygous for a targeted null mutation exhibit impaired phagocytosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    38
  • cDNA Data
    30
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15162 NCBI Gene Model | MGI Sequence Detail 42974 C57BL/6J ±  kb
    transcript NM_010407 RefSeq | MGI Sequence Detail 2107 ZRU/MplStud  
    polypeptide P08103 UniProt | EBI | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 2
      cDNA 32
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10666, MGD-MRK-10667, MGD-MRK-1590, MGI:2139076
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 69
    • Earliest
      J:8946 Holtzman DA, et al., Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Proc Natl Acad Sci U S A. 1987 Dec;84(23):8325-9
    • Latest
      J:338320 Chen M, et al., HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. Nat Commun. 2023 Jul 18;14(1):4297
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory