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Hoxd11 Gene Detail
Summary
  • Symbol
    Hoxd11
  • Name
    homeobox D11
  • Synonyms
    E230017H14Rik, Hox-4.6, Hox-5.4, Hox-5.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96203
    NCBI Gene: 15431
  • Member of
    Hoxd cluster
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74509902-74517360 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96203
 protein coding gene Chr2:74509901-74517360 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025847
 protein coding gene Chr2:74993757-75001219 (+)
A/J MGP_AJ_G0025825
 protein coding gene Chr2:72060817-72068344 (+)
AKR/J MGP_AKRJ_G0025793
 protein coding gene Chr2:74014084-74021566 (+)
BALB/cJ MGP_BALBcJ_G0025819
 protein coding gene Chr2:72247737-72254987 (+)
C3H/HeJ MGP_C3HHeJ_G0025579
 protein coding gene Chr2:74201919-74209385 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026266
 protein coding gene Chr2:77227886-77235345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023669
 protein coding gene Chr2:69483911-69491484 (+)
CAST/EiJ MGP_CASTEiJ_G0025043
 protein coding gene Chr2:74516545-74526529 (+)
CBA/J MGP_CBAJ_G0025560
 protein coding gene Chr2:80049034-80056500 (+)
DBA/2J MGP_DBA2J_G0025691
 protein coding gene Chr2:71667412-71674897 (+)
FVB/NJ MGP_FVBNJ_G0025653
 protein coding gene Chr2:71057127-71064612 (+)
LP/J MGP_LPJ_G0025779
 protein coding gene Chr2:74857855-74865354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025684
 protein coding gene Chr2:81962636-81970130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026323
 protein coding gene Chr2:74129616-74137071 (+)
PWK/PhJ MGP_PWKPhJ_G0024784
 protein coding gene Chr2:71597802-71605403 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024592
 protein coding gene Chr2:74363454-74370865 (+)
WSB/EiJ MGP_WSBEiJ_G0025111
 protein coding gene Chr2:74565574-74573041 (+)



Homology
more
  • Human Ortholog
    HOXD11, homeobox D11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXD11, homeobox D11
  • Synonyms
    HOX4, HOX4F
  • Links
    NCBI Gene ID: 3237
    neXtProt AC: NX_P31277
    UniProt: P31277

  • Chr Location
    2q31.1; chr2:176104216-176115679 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 5 genetic backgrounds
    68 phenotypes from multigenic genotypes
    4 images
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit homeotic transformations of sacral vertebrae, malformations of distal limbs, and reduced fertility in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1379
  • Tissues
    334
  • cDNA Data
    18
  • Literature Summary
    190
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15431 NCBI Gene Model | MGI Sequence Detail 7459 C57BL/6J ±  kb
    transcript NM_008273 RefSeq | MGI Sequence Detail 3959 Not Specified  
    polypeptide P23813 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 11
      cDNA 20
      Primer pair 12
      Other 41

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10853, MGD-MRK-10861, MGD-MRK-10904, MGI:2442499
    References
    more
    • Summaries
      All 284
      Developmental Gene Expression 190
      Gene Ontology 15
      Phenotypes 93
    • Earliest
      J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
    • Latest
      J:354194 Oikonomakos I, et al., In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory