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Hp Gene Detail
Summary
  • Symbol
    Hp
  • Name
    haptoglobin
  • Synonyms
    HP-1, preHP2, zonulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96211
    NCBI Gene: 15439
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110301760-110305804 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.11 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96211
 protein coding gene Chr8:110301760-110305804 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034108
 protein coding gene Chr8:112175288-112179330 (-)
A/J MGP_AJ_G0034088
 protein coding gene Chr8:107617198-107621242 (-)
AKR/J MGP_AKRJ_G0034014
 protein coding gene Chr8:110784339-110788383 (-)
BALB/cJ MGP_BALBcJ_G0034081
 protein coding gene Chr8:107840440-107844482 (-)
C3H/HeJ MGP_C3HHeJ_G0033793
 protein coding gene Chr8:111494486-111498531 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034601
 protein coding gene Chr8:116141141-116145183 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031543
 protein coding gene Chr8:100668861-100672757 (-)
CAST/EiJ MGP_CASTEiJ_G0033120
 protein coding gene Chr8:111091232-111095248 (-)
CBA/J MGP_CBAJ_G0033766
 protein coding gene Chr8:120036107-120040151 (-)
DBA/2J MGP_DBA2J_G0033921
 protein coding gene Chr8:106957712-106961760 (-)
FVB/NJ MGP_FVBNJ_G0033866
 protein coding gene Chr8:105907305-105911349 (-)
LP/J MGP_LPJ_G0034012
 protein coding gene Chr8:112352313-112356357 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033911
 protein coding gene Chr8:123056883-123060927 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034620
 protein coding gene Chr8:110747089-110751132 (-)
PWK/PhJ MGP_PWKPhJ_G0032822
 protein coding gene Chr8:106521037-106525069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032661
 protein coding gene Chr8:109429872-109435500 (-)
WSB/EiJ MGP_WSBEiJ_G0033235
 protein coding gene Chr8:111430601-111434645 (-)



Homology
more
  • Human Ortholog
    HP, haptoglobin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HP, haptoglobin
  • Synonyms
    BP, HP2ALPHA2, HPA1S
  • Links
    NCBI Gene ID: 3240
    neXtProt AC: NX_P00738
    UniProt: P00738

  • Chr Location
    16q22.2; chr16:72054505-72061055 (+)  GRCh38
  • Human Ortholog
    HPR, haptoglobin-related protein
  • Synonyms
    A-259H10.2, HP
  • Links
    NCBI Gene ID: 3250
    neXtProt AC: NX_P00739
    UniProt: P00739

  • Chr Location
    16q22.2; chr16:72063148-72077246 (+)  GRCh38
Human Diseases
more
  • Diseases
    9 with human HP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele exhibit partial postnatal lethality, susceptibility to induced acute hemolysis, and altered renal iron loading during aging and after ischemic injury. Homozygotes for a knock-in allele show reduced cholesterol efflux and enhanced nephropathy in STZ-induced diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    33
  • cDNA Data
    305
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15439 NCBI Gene Model | MGI Sequence Detail 4045 C57BL/6J ±  kb
    transcript NM_017370 RefSeq | MGI Sequence Detail 1365 ZRU/MplStud  
    polypeptide Q61646 UniProt | EBI | MGI Sequence Detail 347 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 315
      Genomic 2
      cDNA 309
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10912
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 33
    • Earliest
      J:24824 Peacock AC, et al., Haptoglobin levels in serum of various strains of mice. Science. 1967 Dec 29;158(809):1703-4
    • Latest
      J:298504 Kerchberger VE, et al., Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis. JCI Insight. 2019 Nov 1;4(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory