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Hv1 Gene Detail
Summary
  • Symbol
    Hv1
  • Name
    hepatitis virus (MHV-2) susceptibility
  • Synonyms
    Hv-1
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:96288
    NCBI Gene: 107755
  • Alliance
    gene page
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome Unknown
Mutations,
Alleles, and
Phenotypes
less
The locus affects susceptibility to lethal infection by mouse hepatitis virus 2 (MHV2). PRI and C3H.PRI-Hv1s carry the susceptibility allele; C3H/An carries the resistant allele. Heterozygotes are susceptible. Virus is effectively taken up by all macrophages, but does not multiply in resistant ones.
Sequences &
Gene Models
less
Other
Accession IDs
less
MGD-MRK-11016, MGD-MRK-11018
References
more
  • Summaries
    All 9
  • Earliest
    J:13128 Kantoch M, et al., Conversion of genetic resistance of mammalian cells to susceptibility to a virus infection. Proc Natl Acad Sci U S A. 1962 Sep 15;48:1553-1559
  • Latest
    J:43577 Ohtsuka N, et al., Mouse susceptibility to mouse hepatitis virus infection is linked to viral receptor genotype. J Virol. 1997 Nov;71(11):8860-3
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory