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Id3 Gene Detail
Summary
  • Symbol
    Id3
  • Name
    inhibitor of DNA binding 3
  • Synonyms
    bHLHb25, HLH462, Idb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96398
    NCBI Gene: 15903
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135871133-135872703 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.34 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96398
 protein coding gene Chr4:135870808-135873066 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028960
 protein coding gene Chr4:138666911-138669170 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0028871
 protein coding gene Chr4:136609198-136611458 (+)
BALB/cJ MGP_BALBcJ_G0028943
 protein coding gene Chr4:133437526-133439795 (+)
C3H/HeJ MGP_C3HHeJ_G0028657
 protein coding gene Chr4:136888238-136890498 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029384
 protein coding gene Chr4:143590386-143592644 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026655
 protein coding gene Chr4:125811023-125813276 (+)
CAST/EiJ MGP_CASTEiJ_G0028089
 protein coding gene Chr4:135029789-135032048 (+)
CBA/J MGP_CBAJ_G0028622
 protein coding gene Chr4:147518467-147520727 (+)
DBA/2J MGP_DBA2J_G0028771
 protein coding gene Chr4:133194159-133196428 (+)
FVB/NJ MGP_FVBNJ_G0028738
 protein coding gene Chr4:132127612-132129881 (+)
LP/J MGP_LPJ_G0028870
 protein coding gene Chr4:138758468-138760727 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028764
 protein coding gene Chr4:151772525-151774658 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029422
 protein coding gene Chr4:137069619-137071878 (+)
PWK/PhJ MGP_PWKPhJ_G0027809
 protein coding gene Chr4:129963119-129965379 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027635
 protein coding gene Chr4:132885653-132887905 (+)
WSB/EiJ MGP_WSBEiJ_G0028167
 protein coding gene Chr4:137238604-137240864 (+)



Homology
more
  • Human Ortholog
    ID3, inhibitor of DNA binding 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ID3, inhibitor of DNA binding 3
  • Synonyms
    bHLHb25, HEIR-1
  • Links
    NCBI Gene ID: 3399
    neXtProt AC: NX_Q02535
    UniProt: Q02535

  • Chr Location
    1p36.12; chr1:23557926-23559501 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Id3 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 6 alleles in 9 genetic backgrounds
    38 phenotypes from multigenic genotypes
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit compromised humoral immunity. Homozygotes for knockout alleles of both Id1 and Id3 die by embryonic day 13.5 with vascular malformations of the forebrain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1355
  • Tissues
    466
  • cDNA Data
    200
  • Literature Summary
    106
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15903 NCBI Gene Model | MGI Sequence Detail 1571 C57BL/6J ±  kb
    transcript NM_001429353 RefSeq | MGI Sequence Detail 1449 C57BL/6  
    polypeptide P41133 UniProt | EBI | MGI Sequence Detail 119 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 224
      Genomic 1
      cDNA 205
      Primer pair 13
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11155
    References
    more
    • Summaries
      All 278
      Developmental Gene Expression 106
      Diseases 3
      Gene Ontology 20
      Phenotypes 107
    • Earliest
      J:13202 Christy BA, et al., An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1815-9
    • Latest
      J:354623 Ran L, et al., The transcription regulator ID3 maintains tumor-specific memory CD8(+) T cells in draining lymph nodes during tumorigenesis. Cell Rep. 2024 Sep 24;43(9):114690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory