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Igfbp3 Gene Detail
Summary
  • Symbol
    Igfbp3
  • Name
    insulin-like growth factor binding protein 3
  • Synonyms
    IGFBP-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96438
    NCBI Gene: 16009
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:7156086-7163923 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 4.75 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96438
 protein coding gene Chr11:7156086-7165498 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018034
 protein coding gene Chr11:4406483-4414311 (-)
A/J MGP_AJ_G0018007
 protein coding gene Chr11:4186108-4193935 (-)
AKR/J MGP_AKRJ_G0017971
 protein coding gene Chr11:4382001-4389828 (-)
BALB/cJ MGP_BALBcJ_G0017975
 protein coding gene Chr11:4185334-4193171 (-)
C3H/HeJ MGP_C3HHeJ_G0017788
 protein coding gene Chr11:4286137-4293935 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018427
 protein coding gene Chr11:4491468-4499305 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016085
 protein coding gene Chr11:4056107-4063857 (-)
CAST/EiJ MGP_CASTEiJ_G0017350
 protein coding gene Chr11:4278187-4285985 (-)
CBA/J MGP_CBAJ_G0017763
 protein coding gene Chr11:4986350-4994187 (-)
DBA/2J MGP_DBA2J_G0017873
 protein coding gene Chr11:4102714-4110551 (-)
FVB/NJ MGP_FVBNJ_G0017865
 protein coding gene Chr11:4144021-4151819 (-)
LP/J MGP_LPJ_G0017944
 protein coding gene Chr11:4460165-4468002 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017891
 protein coding gene Chr11:4520589-4528416 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018467
 protein coding gene Chr11:4434560-4442398 (-)
PWK/PhJ MGP_PWKPhJ_G0017130
 protein coding gene Chr11:4144200-4152048 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016927
 protein coding gene Chr11:4357925-4365778 (-)
WSB/EiJ MGP_WSBEiJ_G0017404
 protein coding gene Chr11:4241109-4248942 (-)



Homology
more
  • Human Ortholog
    IGFBP3, insulin like growth factor binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGFBP3, insulin like growth factor binding protein 3
  • Synonyms
    BP-53, IBP-3, IBP3, IGFBP-3
  • Links
    NCBI Gene ID: 3486
    neXtProt AC: NX_P17936
    UniProt: P17936

  • Chr Location
    7p12.3; chr7:45912245-45921874 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human IGFBP3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit normal body weight. Mice homozygous for another knock-out allele exhibit increased body weight, and show altered hepatic carbohydrate and lipid metabolism when fed a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    86
  • cDNA Data
    138
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020427 Ensembl Gene Model | MGI Sequence Detail 7838 C57BL/6J ±  kb
    transcript ENSMUST00000020702 Ensembl | MGI Sequence Detail 2421 Not Applicable  
    polypeptide ENSMUSP00000020702 Ensembl | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008949 insulin-like growth factor-binding protein 3
      (term hierarchy)
    • InterPro Domains
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR012211 Insulin-like growth factor binding protein 3
      IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000716 Thyroglobulin type-1
      IPR036857 Thyroglobulin type-1 superfamily
    • GlyGen
      P47878 3 sites
    Molecular
    Reagents
    less
    • All nucleic 155
      Genomic 5
      cDNA 138
      Primer pair 9
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11235, MGI:2144251
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 57
      Gene Ontology 15
      Phenotypes 31
    • Earliest
      J:3735 Donahue LR, et al., Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993 Jan;136(1):91-104
    • Latest
      J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory