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Igkc Gene Detail
Summary
  • Symbol
    Igkc
  • Name
    immunoglobulin kappa constant
  • Feature Type
    gene segment
  • IDs
    MGI:96495
    NCBI Gene: 16071
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:70703419-70703738 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.04 cM, cytoband C
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96495
 gene segment Chr6:70703419-70703950 (+)
129S1/SvImJ MGP_129S1SvImJ_G0000015
 gene segment Chr6:71140578-71141109 (+)
A/J MGP_AJ_G0000015
 gene segment Chr6:68431659-68432190 (+)
AKR/J MGP_AKRJ_G0000014
 gene segment Chr6:70402353-70402884 (+)
BALB/cJ MGP_BALBcJ_G0000015
 gene segment Chr6:68457108-68457639 (+)
C3H/HeJ MGP_C3HHeJ_G0000015
 gene segment Chr6:113864013-113864544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000015
 gene segment Chr6:73027106-73027637 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0000012
 gene segment Chr6:67619625-67620171 (+)
CAST/EiJ MGP_CASTEiJ_G0000013
 gene segment Chr6:70238330-70238861 (+)
CBA/J MGP_CBAJ_G0000015
 gene segment Chr6:75894752-75895283 (+)
DBA/2J MGP_DBA2J_G0000015
 gene segment Chr6:67807249-67807780 (+)
FVB/NJ MGP_FVBNJ_G0000015
 gene segment Chr6:67174243-67174774 (+)
LP/J MGP_LPJ_G0000015
 gene segment Chr6:71080242-71080773 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0000014
 gene segment Chr6:79453644-79454175 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0000015
 gene segment Chr6:70225927-70226458 (+)
PWK/PhJ MGP_PWKPhJ_G0000014
 gene segment Chr6:66663704-66664235 (+)
SPRET/EiJ MGP_SPRETEiJ_G0000012
 gene segment Chr6:68954243-68954771 (+)
WSB/EiJ MGP_WSBEiJ_G0000015
 gene segment Chr6:70564411-70564942 (+)



Homology
more
  • Human Ortholog
    IGKC, immunoglobulin kappa constant
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGKC, immunoglobulin kappa constant
  • Synonyms
    HCAK1, IGKCD, Km
  • Links
    NCBI Gene ID: 3514
    UniProt: P01834

  • Chr Location
    2p11.2; chr2:88857161-88857683 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene prevents the expression of rearranged kappa genes, leading to exclusive production of lambda chain-expressing B cells and alterations in immunization titers, germinal center development, and somatic hypermutation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    48
  • cDNA Data
    3
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      34
    • RefSeq
      1
    • UniProt
      4
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16071 NCBI Gene Model | MGI Sequence Detail 320 C57BL/6J ±  kb
    transcript BC110685 GenBank | ENA | DDBJ | MGI Sequence Detail 1017 CZECHII  
    polypeptide P01837 UniProt | EBI | MGI Sequence Detail 107 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      Genomic 61
      cDNA 32
      Primer pair 3
      Other 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-11293
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 49
    • Earliest
      J:6069 Seidman JG, et al., The arrangement and rearrangement of antibody genes. Nature. 1978 Dec 21-28;276(5690):790-5
    • Latest
      J:261505 Clark AG, et al., A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities. Mol Immunol. 2017 Nov;91:49-56
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory