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Itgal Gene Detail
Summary
  • Symbol
    Itgal
  • Name
    integrin alpha L
  • Synonyms
    Cd11a, LFA-1, Ly-15, Ly-21
  • Feature Type
    protein coding gene
  • IDs
    MGI:96606
    NCBI Gene: 16408
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126895432-126934310 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.44 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1253 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96606
 protein coding gene Chr7:126895404-126934310 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033031
 protein coding gene Chr7:131638327-131682541 (+)
A/J MGP_AJ_G0033014
 protein coding gene Chr7:128130752-128169886 (+)
AKR/J MGP_AKRJ_G0032946
 protein coding gene Chr7:131395358-131449668 (+)
BALB/cJ MGP_BALBcJ_G0033019
 protein coding gene Chr7:127810278-127850370 (+)
C3H/HeJ MGP_C3HHeJ_G0032729
 protein coding gene Chr7:131323487-131363772 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033525
 protein coding gene Chr7:136750350-136798478 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030497
 protein coding gene Chr7:129340031-129379450 (+)
CAST/EiJ MGP_CASTEiJ_G0032058
 protein coding gene Chr7:123126225-123168947 (+)
CBA/J MGP_CBAJ_G0032702
 protein coding gene Chr7:141371889-141413017 (+)
DBA/2J MGP_DBA2J_G0032854
 protein coding gene Chr7:126105539-126144528 (+)
FVB/NJ MGP_FVBNJ_G0032807
 protein coding gene Chr7:125958069-125996730 (+)
LP/J MGP_LPJ_G0032948
 protein coding gene Chr7:133099922-133139788 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032839
 protein coding gene Chr7:142493612-142538738 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033544
 protein coding gene Chr7:130407383-130447399 (+)
PWK/PhJ MGP_PWKPhJ_G0031766
 protein coding gene Chr7:119114925-119157144 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031611
 protein coding gene Chr7:117244694-117283326 (+)
WSB/EiJ MGP_WSBEiJ_G0032170
 protein coding gene Chr7:131372531-131430694 (+)



Homology
more
  • Human Ortholog
    ITGAL, integrin subunit alpha L
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGAL, integrin subunit alpha L
  • Synonyms
    CD11A, LFA-1, LFA1A
  • Links
    NCBI Gene ID: 3683
    neXtProt AC: NX_P20701
    UniProt: P20701

  • Chr Location
    16p11.2; chr16:30472658-30523567 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 7 alleles in 9 genetic backgrounds
    3 phenotypes from multigenic genotypes
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations of this gene lead to increased leukocyte cell number, alter T cell activation, leukocyte migration and adhesion, spleen and lymph node morphology, and may affect humoral immune responses, metastatic potential, and susceptibility to endotoxin shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    11
  • cDNA Data
    41
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030830 Ensembl Gene Model | MGI Sequence Detail 38879 C57BL/6J ±  kb
    transcript ENSMUST00000120857 Ensembl | MGI Sequence Detail 4533 Not Applicable  
    polypeptide ENSMUSP00000113396 Ensembl | MGI Sequence Detail 1201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000001011 integrin alpha-L
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      P24063 16 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 41
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11485, MGD-MRK-11953, MGD-MRK-11960, MGD-MRK-1830
    References
    more
    • Summaries
      All 209
      Developmental Gene Expression 5
      Gene Ontology 14
      Phenotypes 117
    • Earliest
      J:6511 Potter TA, et al., Ly-15: a new murine lymphocyte alloantigenic locus. Transplantation. 1981 May;31(5):339-42
    • Latest
      J:353967 Thierry GR, et al., Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis. Immunity. 2024 Jul 27;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory