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Kcnc2 Gene Detail
Summary
  • Symbol
    Kcnc2
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 2
  • Synonyms
    KShIIIA, Kv3.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96668
    NCBI Gene: 268345
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:112107026-112302929 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 60.30 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5869 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96668
 protein coding gene Chr10:112105803-112302929 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017728
 protein coding gene Chr10:114801641-114994205 (+)
A/J MGP_AJ_G0017705
 protein coding gene Chr10:110438420-110625210 (+)
AKR/J MGP_AKRJ_G0017667
 protein coding gene Chr10:113679970-113869667 (+)
BALB/cJ MGP_BALBcJ_G0017668
 protein coding gene Chr10:110792386-110979153 (+)
C3H/HeJ MGP_C3HHeJ_G0017493
 protein coding gene Chr10:113818327-114009244 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018125
 protein coding gene Chr10:118784909-118970124 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015805
 protein coding gene Chr10:105192613-105373239 (+)
CAST/EiJ MGP_CASTEiJ_G0017055
 protein coding gene Chr10:114016716-114193644 (+)
CBA/J MGP_CBAJ_G0017462
 protein coding gene Chr10:123484347-123673779 (+)
DBA/2J MGP_DBA2J_G0017567
 protein coding gene Chr10:109593756-109772090 (+)
FVB/NJ MGP_FVBNJ_G0017562
 protein coding gene Chr10:108547340-108731208 (+)
LP/J MGP_LPJ_G0017642
 protein coding gene Chr10:115441900-115636912 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017591
 protein coding gene Chr10:125997227-126202822 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018163
 protein coding gene Chr10:113660930-113845260 (+)
PWK/PhJ MGP_PWKPhJ_G0016837
 protein coding gene Chr10:109629114-109816021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016627
 protein coding gene Chr10:112430945-112616044 (+)
WSB/EiJ MGP_WSBEiJ_G0017115
 protein coding gene Chr10:113842741-114046203 (+)



Homology
more
  • Human Ortholog
    KCNC2, potassium voltage-gated channel subfamily C member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNC2, potassium voltage-gated channel subfamily C member 2
  • Synonyms
    DEE103, KV3.2
  • Links
    NCBI Gene ID: 3747
    neXtProt AC: NX_Q96PR1
    UniProt: Q96PR1

  • Chr Location
    12q21.1; chr12:75040077-75209839 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired fast spiking in cortical interneurons, distorted cortical rhythmic activity, enhanced susceptibility to seizures, increased anxiety in the open field, and abnormal sleep patterns.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    90
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    36
  • cDNA Data
    12
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035681 Ensembl Gene Model | MGI Sequence Detail 195904 C57BL/6J ±  kb
transcript ENSMUST00000092175 Ensembl | MGI Sequence Detail 5046 Not Applicable  
polypeptide ENSMUSP00000089814 Ensembl | MGI Sequence Detail 642 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 13
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-11572, MGI:2143797
References
more
  • Summaries
    All 68
    Developmental Gene Expression 9
    Gene Ontology 14
    Phenotypes 21
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory