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Krt12 Gene Detail
Summary
  • Symbol
    Krt12
  • Name
    keratin 12
  • Synonyms
    K12, Krt1-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:96687
    NCBI Gene: 268482
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:99306492-99313085 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.92 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    350 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96687
 protein coding gene Chr11:99306490-99313419 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019092
 protein coding gene Chr11:102081014-102087593 (-)
A/J MGP_AJ_G0019060
 protein coding gene Chr11:97783245-97789814 (-)
AKR/J MGP_AKRJ_G0019030
 protein coding gene Chr11:100818047-100824631 (-)
BALB/cJ MGP_BALBcJ_G0019034
 protein coding gene Chr11:98292842-98299411 (-)
C3H/HeJ MGP_C3HHeJ_G0018847
 protein coding gene Chr11:100969209-100975779 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019485
 protein coding gene Chr11:105220731-105227324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017117
 protein coding gene Chr11:95345288-95351846 (-)
CAST/EiJ MGP_CASTEiJ_G0018402
 protein coding gene Chr11:101966860-101973462 (-)
CBA/J MGP_CBAJ_G0018818
 protein coding gene Chr11:109606044-109612623 (-)
DBA/2J MGP_DBA2J_G0018926
 protein coding gene Chr11:97350481-97357047 (-)
FVB/NJ MGP_FVBNJ_G0018915
 protein coding gene Chr11:96860982-96867560 (-)
LP/J MGP_LPJ_G0018996
 protein coding gene Chr11:102548582-102555159 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018942
 protein coding gene Chr11:109276535-109283148 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019525
 protein coding gene Chr11:101176931-101183507 (-)
PWK/PhJ MGP_PWKPhJ_G0018173
 protein coding gene Chr11:98422911-98429488 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017961
 protein coding gene Chr11:100934183-100940643 (-)
WSB/EiJ MGP_WSBEiJ_G0018450
 protein coding gene Chr11:101153327-101159897 (-)



Homology
more
  • Human Ortholog
    KRT12, keratin 12
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT12, keratin 12
  • Synonyms
    K12, MECD1
  • Links
    NCBI Gene ID: 3859
    neXtProt AC: NX_Q99456
    UniProt: Q99456

  • Chr Location
    17q21.2; chr17:40861303-40867223 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KRT12 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display abnormal and fragile corneal epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    23
  • cDNA Data
    16
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020912 Ensembl Gene Model | MGI Sequence Detail 6594 C57BL/6J ±  kb
    transcript ENSMUST00000017741 Ensembl | MGI Sequence Detail 1852 Not Applicable  
    polypeptide ENSMUSP00000017741 Ensembl | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 5
      cDNA 16
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11642, MGI:2144270
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 46
      Diseases 1
      Gene Ontology 6
      Phenotypes 32
    • Earliest
      J:16837 Liu CY, et al., Cornea-specific expression of K12 keratin during mouse development. Curr Eye Res. 1993 Nov;12(11):963-74
    • Latest
      J:346907 Sunny SS, et al., Ovol2 promoter mutations in mice and human illuminate species-specific phenotypic divergence. Hum Mol Genet. 2024 Feb 28;33(6):491-500
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory