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Krt15 Gene Detail
Summary
  • Symbol
    Krt15
  • Name
    keratin 15
  • Synonyms
    K15, Krt1-15
  • Feature Type
    protein coding gene
  • IDs
    MGI:96689
    NCBI Gene: 16665
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100022584-100026754 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.41 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96689
 protein coding gene Chr11:100022584-100026775 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019142
 protein coding gene Chr11:102880187-102884357 (-)
A/J MGP_AJ_G0019110
 protein coding gene Chr11:98537461-98541652 (-)
AKR/J MGP_AKRJ_G0019079
 protein coding gene Chr11:101582151-101586321 (-)
BALB/cJ MGP_BALBcJ_G0019084
 protein coding gene Chr11:99053844-99058023 (-)
C3H/HeJ MGP_C3HHeJ_G0018893
 protein coding gene Chr11:101779511-101783681 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019533
 protein coding gene Chr11:106047742-106051912 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017160
 protein coding gene Chr11:95991746-95995922 (-)
CAST/EiJ MGP_CASTEiJ_G0018447
 protein coding gene Chr11:102760931-102765106 (-)
CBA/J MGP_CBAJ_G0018862
 protein coding gene Chr11:110482924-110487103 (-)
DBA/2J MGP_DBA2J_G0018975
 protein coding gene Chr11:98112580-98116750 (-)
FVB/NJ MGP_FVBNJ_G0018964
 protein coding gene Chr11:97613263-97617433 (-)
LP/J MGP_LPJ_G0019043
 protein coding gene Chr11:103418748-103422918 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018995
 protein coding gene Chr11:110107272-110111442 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019571
 protein coding gene Chr11:101959569-101963747 (-)
PWK/PhJ MGP_PWKPhJ_G0018210
 protein coding gene Chr11:99143467-99147749 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018002
 protein coding gene Chr11:101659820-101663974 (-)
WSB/EiJ MGP_WSBEiJ_G0018496
 protein coding gene Chr11:101926456-101930626 (-)



Homology
more
  • Human Ortholog
    KRT15, keratin 15
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT15, keratin 15
  • Synonyms
    CK15, K15, K1CO
  • Links
    NCBI Gene ID: 3866
    neXtProt AC: NX_P19012
    UniProt: P19012

  • Chr Location
    17q21.2; chr17:41513745-41522529 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired esophageal epithelial regeneration with thicker epithelia due to enhanced basal cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    972
  • Tissues
    107
  • cDNA Data
    48
  • Literature Summary
    70
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054146 Ensembl Gene Model | MGI Sequence Detail 4171 C57BL/6J ±  kb
    transcript ENSMUST00000107411 Ensembl | MGI Sequence Detail 1700 Not Applicable  
    polypeptide ENSMUSP00000103034 Ensembl | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 5
      cDNA 48
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11644, MGI:2144217
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 70
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:16891 Nozaki M, et al., The complete sequence of the gene encoding mouse cytokeratin 15. Gene. 1994 Jan 28;138(1-2):197-200
    • Latest
      J:337667 Ievlev V, et al., Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells. JCI Insight. 2023 Jan 24;8(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory