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Krt4 Gene Detail
Summary
  • Symbol
    Krt4
  • Name
    keratin 4
  • Synonyms
    K4, Krt-2.4, Krt2-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96701
    NCBI Gene: 16682
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101826970-101833170 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96701
 protein coding gene Chr15:101826970-101833170 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022392
 protein coding gene Chr15:104051670-104057896 (-)
A/J MGP_AJ_G0022355
 protein coding gene Chr15:99956404-99962603 (-)
AKR/J MGP_AKRJ_G0022330
 protein coding gene Chr15:102992191-102998390 (-)
BALB/cJ MGP_BALBcJ_G0022358
 protein coding gene Chr15:100018799-100025025 (-)
C3H/HeJ MGP_C3HHeJ_G0022125
 protein coding gene Chr15:103060125-103066324 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022807
 protein coding gene Chr15:107921354-107927553 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020330
 protein coding gene Chr15:95753800-95760089 (-)
CAST/EiJ MGP_CASTEiJ_G0021651
 protein coding gene Chr15:103916531-103922728 (-)
CBA/J MGP_CBAJ_G0022094
 protein coding gene Chr15:111676498-111682697 (-)
DBA/2J MGP_DBA2J_G0022225
 protein coding gene Chr15:99258066-99264265 (-)
FVB/NJ MGP_FVBNJ_G0022201
 protein coding gene Chr15:98316129-98322328 (-)
LP/J MGP_LPJ_G0022294
 protein coding gene Chr15:104206430-104212656 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022223
 protein coding gene Chr15:115299191-115305390 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022819
 protein coding gene Chr15:103017667-103023889 (-)
PWK/PhJ MGP_PWKPhJ_G0021391
 protein coding gene Chr15:99405400-99411599 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021223
 protein coding gene Chr15:102849929-102856173 (-)
WSB/EiJ MGP_WSBEiJ_G0021701
 protein coding gene Chr15:103640218-103646416 (-)



Homology
more
  • Human Ortholog
    KRT4, keratin 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT4, keratin 4
  • Synonyms
    CK-4, CK4, CYK4, K4, WSN1
  • Links
    NCBI Gene ID: 3851
    neXtProt AC: NX_P19013
    UniProt: P19013

  • Chr Location
    12q13.13; chr12:52806549-52814116 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Krt4 mouse models; 1 with human KRT4 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display hyperplasia throughout the epithelium of the esophagus and tongue. Mice homozygous or heterozygous for a dominant mutation display oral leukoplakia and homozygotes display postnatal growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    60
  • cDNA Data
    24
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16682 NCBI Gene Model | MGI Sequence Detail 6201 C57BL/6J ±  kb
    transcript NM_008475 RefSeq | MGI Sequence Detail 2147 ZRU/MplStud  
    polypeptide P07744 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 4
      cDNA 26
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11636, MGD-MRK-11656, MGD-MRK-38408, MGI:109363, MGI:2146191
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 21
      Diseases 2
      Gene Ontology 4
      Phenotypes 31
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:328556 Sunny SS, et al., Multiple roles of Pax6 in postnatal cornea development. Dev Biol. 2022 Aug 29;491:1-12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory