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Krt5 Gene Detail
Summary
  • Symbol
    Krt5
  • Name
    keratin 5
  • Synonyms
    3300001P10Rik, K5, Krt2-5, Tfip8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96702
    NCBI Gene: 110308
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101615505-101621333 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96702
 protein coding gene Chr15:101615504-101621340 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022383
 protein coding gene Chr15:103831135-103839234 (-)
A/J MGP_AJ_G0022346
 protein coding gene Chr15:99734065-99739834 (-)
AKR/J MGP_AKRJ_G0022321
 protein coding gene Chr15:102765962-102771764 (-)
BALB/cJ MGP_BALBcJ_G0022349
 protein coding gene Chr15:99806374-99813902 (-)
C3H/HeJ MGP_C3HHeJ_G0022116
 protein coding gene Chr15:102841620-102848539 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022798
 protein coding gene Chr15:107689343-107695197 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020321
 protein coding gene Chr15:95546769-95552358 (-)
CAST/EiJ MGP_CASTEiJ_G0021642
 protein coding gene Chr15:103686037-103694077 (-)
CBA/J MGP_CBAJ_G0022085
 protein coding gene Chr15:111446542-111452861 (-)
DBA/2J MGP_DBA2J_G0022216
 protein coding gene Chr15:99047063-99053964 (-)
FVB/NJ MGP_FVBNJ_G0022192
 protein coding gene Chr15:98099631-98107693 (-)
LP/J MGP_LPJ_G0022285
 protein coding gene Chr15:103987106-103994007 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022214
 protein coding gene Chr15:115080921-115086649 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022810
 protein coding gene Chr15:102785230-102791072 (-)
PWK/PhJ MGP_PWKPhJ_G0021382
 protein coding gene Chr15:99191159-99197216 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021214
 protein coding gene Chr15:102640075-102645875 (-)
WSB/EiJ MGP_WSBEiJ_G0021692
 protein coding gene Chr15:103424264-103430860 (-)



Homology
more
  • Human Ortholog
    KRT5, keratin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT5, keratin 5
  • Synonyms
    CK5, DDD, DDD1, EBS1, EBS2, EBS2A, EBS2B, EBS2C, EBS2D, EBS2E, EBS2F, K5, KRT5A
  • Links
    NCBI Gene ID: 3852
    neXtProt AC: NX_P13647
    UniProt: P13647

  • Chr Location
    12q13.13; chr12:52514575-52520530 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Krt5 mouse models; 3 with human KRT5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die within the first hour after birth. They have a loose, fragile epidermal layer and abnormal epithelium in parts of the digestive tract.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1440
  • Tissues
    239
  • cDNA Data
    101
  • Literature Summary
    349
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061527 Ensembl Gene Model | MGI Sequence Detail 5829 C57BL/6J ±  kb
    transcript ENSMUST00000023709 Ensembl | MGI Sequence Detail 2197 Not Applicable  
    polypeptide ENSMUSP00000023709 Ensembl | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      Genomic 5
      cDNA 102
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11657, MGI:1890361, MGI:1916515, MGI:2146203
    References
    more
    • Summaries
      All 487
      Developmental Gene Expression 349
      Diseases 2
      Gene Ontology 16
      Phenotypes 95
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory