About   Help   FAQ
Hikeshi Gene Detail
Summary
  • Symbol
    Hikeshi
  • Name
    heat shock protein nuclear import factor
  • Synonyms
    0610007P06Rik, 1110002N09Rik, Hikeshi, l(7)6Rn, l7Rn6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96738
    NCBI Gene: 67669
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:89567893-89590446 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 50.40 cM, cytoband E1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96738
 protein coding gene Chr7:89566737-89590446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032500
 protein coding gene Chr7:92308391-92341255 (-)
A/J MGP_AJ_G0032474
 protein coding gene Chr7:90095143-90121639 (-)
AKR/J MGP_AKRJ_G0032410
 protein coding gene Chr7:92186765-92216796 (-)
BALB/cJ MGP_BALBcJ_G0032485
 protein coding gene Chr7:89736526-89767814 (-)
C3H/HeJ MGP_C3HHeJ_G0032200
 protein coding gene Chr7:92585341-92614051 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032983
 protein coding gene Chr7:95905474-95931042 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029978
 protein coding gene Chr7:92995797-93018421 (-)
CAST/EiJ MGP_CASTEiJ_G0031527
 protein coding gene Chr7:84024478-84053484 (-)
CBA/J MGP_CBAJ_G0032167
 protein coding gene Chr7:99101561-99130198 (-)
DBA/2J MGP_DBA2J_G0032319
 protein coding gene Chr7:88521413-88546743 (-)
FVB/NJ MGP_FVBNJ_G0032275
 protein coding gene Chr7:88394965-88417190 (-)
LP/J MGP_LPJ_G0032408
 protein coding gene Chr7:93553599-93580071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032309
 protein coding gene Chr7:100110105-100136951 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033005
 protein coding gene Chr7:91482506-91507999 (-)
PWK/PhJ MGP_PWKPhJ_G0031245
 protein coding gene Chr7:81554367-81582233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031088
 protein coding gene Chr7:78805960-78831335 (-)
WSB/EiJ MGP_WSBEiJ_G0031644
 protein coding gene Chr7:92140090-92166908 (-)



Homology
more
  • Human Ortholog
    HIKESHI, heat shock protein nuclear import factor hikeshi
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIKESHI, heat shock protein nuclear import factor hikeshi
  • Synonyms
    C11orf73, HLD13, HSPC138, HSPC179, L7RN6, OPI10
  • Links
    NCBI Gene ID: 51501
    neXtProt AC: NX_Q53FT3
    UniProt: Q53FT3

  • Chr Location
    11q14.2; chr11:86302211-86345943 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HIKESHI associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation die prenatally or neonatally, and exhibit cyanoisis with a significant emphysematous phenotype at birth. The secretory apparatus in Clara cells is also affected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    21
  • cDNA Data
    63
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67669 NCBI Gene Model | MGI Sequence Detail 22554 C57BL/6J ±  kb
    transcript NR_111916 RefSeq | MGI Sequence Detail 2579 ZRU/MplStud  
    polypeptide Q9DD02 UniProt | EBI | MGI Sequence Detail 197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 2
      cDNA 63
      Primer pair 1
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11694, MGD-MRK-11726, MGI:1913365, MGI:1914919
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 38
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory