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Ldha Gene Detail
Summary
  • Symbol
    Ldha
  • Name
    lactate dehydrogenase A
  • Synonyms
    l7R2, lactate dehydrogenase-A, Ldh-1, Ldh1, LDH-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96759
    NCBI Gene: 16828
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46491698-46505051 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.60 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    498 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96759
 protein coding gene Chr7:46490899-46505051 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032274
 protein coding gene Chr7:47243887-47259027 (+)
A/J MGP_AJ_G0032253
 protein coding gene Chr7:46266103-46280557 (+)
AKR/J MGP_AKRJ_G0032189
 protein coding gene Chr7:47577244-47591394 (+)
BALB/cJ MGP_BALBcJ_G0032265
 protein coding gene Chr7:46268264-46282359 (+)
C3H/HeJ MGP_C3HHeJ_G0031978
 protein coding gene Chr7:48050749-48065573 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032755
 protein coding gene Chr7:49511849-49525997 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029771
 protein coding gene Chr7:48804330-48818344 (+)
CAST/EiJ MGP_CASTEiJ_G0031306
 protein coding gene Chr7:39521211-39536971 (+)
CBA/J MGP_CBAJ_G0031943
 protein coding gene Chr7:51176594-51191986 (+)
DBA/2J MGP_DBA2J_G0032100
 protein coding gene Chr7:45943328-45957503 (+)
FVB/NJ MGP_FVBNJ_G0032054
 protein coding gene Chr7:45751967-45766975 (+)
LP/J MGP_LPJ_G0032181
 protein coding gene Chr7:47941727-47955869 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032091
 protein coding gene Chr7:49796292-49810721 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032772
 protein coding gene Chr7:46779344-46793490 (+)
PWK/PhJ MGP_PWKPhJ_G0031029
 protein coding gene Chr7:39324094-39339486 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030869
 protein coding gene Chr7:34802698-34816230 (+)
WSB/EiJ MGP_WSBEiJ_G0031426
 protein coding gene Chr7:47294920-47315740 (+)



Homology
more
  • Human Ortholog
    LDHA, lactate dehydrogenase A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDHA, lactate dehydrogenase A
  • Synonyms
    GSD11, HEL-S-133P, LDHM, PIG19
  • Links
    NCBI Gene ID: 3939
    neXtProt AC: NX_P00338
    UniProt: P00338

  • Chr Location
    11p15.1; chr11:18394560-18408425 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 13 alleles in 13 genetic backgrounds
    1 phenotype from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    130
  • cDNA Data
    1177
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16828 NCBI Gene Model | MGI Sequence Detail 13354 C57BL/6J ±  kb
    transcript NM_001136069 RefSeq | MGI Sequence Detail 1854 ZRU/MplStud  
    polypeptide P06151 UniProt | EBI | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1198
      Genomic 12
      cDNA 1178
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11762, MGD-MRK-11768, MGI:1890511
    References
    more
    • Summaries
      All 170
      Developmental Gene Expression 43
      Gene Ontology 13
      Phenotypes 62
    • Earliest
      J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
    • Latest
      J:355682 Li H, et al., AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases. Nature. 2024 Sep 25;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory