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Mafg Gene Detail
Summary
  • Symbol
    Mafg
  • Name
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
  • Synonyms
    C630022N07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96911
    NCBI Gene: 17134
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120515943-120524426 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96911
 protein coding gene Chr11:120515943-120525771 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019517
 protein coding gene Chr11:125105175-125113615 (-)
A/J MGP_AJ_G0019485
 protein coding gene Chr11:119535198-119543669 (-)
AKR/J MGP_AKRJ_G0019455
 protein coding gene Chr11:123142237-123151386 (-)
BALB/cJ MGP_BALBcJ_G0019460
 protein coding gene Chr11:119892501-119900954 (-)
C3H/HeJ MGP_C3HHeJ_G0019266
 protein coding gene Chr11:123465862-123475618 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019908
 protein coding gene Chr11:128888981-128897422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017534
 protein coding gene Chr11:116524458-116532907 (-)
CAST/EiJ MGP_CASTEiJ_G0018820
 protein coding gene Chr11:124968092-124976554 (-)
CBA/J MGP_CBAJ_G0019237
 protein coding gene Chr11:133924652-133933083 (-)
DBA/2J MGP_DBA2J_G0019349
 protein coding gene Chr11:118903539-118911976 (-)
FVB/NJ MGP_FVBNJ_G0019341
 protein coding gene Chr11:118616275-118624691 (-)
LP/J MGP_LPJ_G0019421
 protein coding gene Chr11:125407112-125415559 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019374
 protein coding gene Chr11:132762542-132774528 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019948
 protein coding gene Chr11:123818415-123826867 (-)
PWK/PhJ MGP_PWKPhJ_G0018586
 protein coding gene Chr11:120341905-120351452 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018378
 protein coding gene Chr11:123585279-123594761 (-)
WSB/EiJ MGP_WSBEiJ_G0018872
 protein coding gene Chr11:123808386-123816823 (-)



Homology
more
  • Human Ortholog
    MAFG, MAF bZIP transcription factor G
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAFG, MAF bZIP transcription factor G
  • Synonyms
    hMAF
  • Links
    NCBI Gene ID: 4097
    neXtProt AC: NX_O15525
    UniProt: O15525

  • Chr Location
    17q25.3; chr17:81918270-81931244 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit a background sensitive increase in perinatal lethality, hemopoietic abnormalities, and locomotor difficulties.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1108
  • Tissues
    248
  • cDNA Data
    12
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051510 Ensembl Gene Model | MGI Sequence Detail 8484 C57BL/6J ±  kb
    transcript ENSMUST00000058162 Ensembl | MGI Sequence Detail 4923 Not Applicable  
    polypeptide ENSMUSP00000053899 Ensembl | MGI Sequence Detail 162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 12
      Primer pair 5
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-12103, MGI:2144026, MGI:2441918
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 15
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
    • Latest
      J:328989 Patel SD, et al., Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Front Cell Dev Biol. 2022;10:981893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory