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Mag Gene Detail
Summary
  • Symbol
    Mag
  • Name
    myelin-associated glycoprotein
  • Synonyms
    Gma, siglec-4a
  • Feature Type
    protein coding gene
  • IDs
    MGI:96912
    NCBI Gene: 17136
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30598601-30614298 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.26 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96912
 protein coding gene Chr7:30598600-30614347 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032050
 protein coding gene Chr7:29931957-29949511 (-)
A/J MGP_AJ_G0032027
 protein coding gene Chr7:29108644-29124795 (-)
AKR/J MGP_AKRJ_G0031960
 protein coding gene Chr7:29855941-29872744 (-)
BALB/cJ MGP_BALBcJ_G0032034
 protein coding gene Chr7:29298000-29315153 (-)
C3H/HeJ MGP_C3HHeJ_G0031753
 protein coding gene Chr7:30316304-30335377 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032500
 protein coding gene Chr7:30913645-30951485 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029550
 protein coding gene Chr7:30119815-30135318 (-)
CAST/EiJ MGP_CASTEiJ_G0031087
 protein coding gene Chr7:23589033-23606906 (-)
CBA/J MGP_CBAJ_G0031719
 protein coding gene Chr7:32383712-32405729 (-)
DBA/2J MGP_DBA2J_G0031871
 protein coding gene Chr7:28854074-28869384 (-)
FVB/NJ MGP_FVBNJ_G0031828
 protein coding gene Chr7:28966691-28984255 (-)
LP/J MGP_LPJ_G0031952
 protein coding gene Chr7:30259803-30275937 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031864
 protein coding gene Chr7:31619236-31639091 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032528
 protein coding gene Chr7:29368945-29384104 (-)
PWK/PhJ MGP_PWKPhJ_G0030811
 protein coding gene Chr7:23875080-23890980 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030646
 protein coding gene Chr7:20369738-20385068 (-)
WSB/EiJ MGP_WSBEiJ_G0031197
 protein coding gene Chr7:29772230-29788562 (-)



Homology
more
  • Human Ortholog
    MAG, myelin associated glycoprotein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAG, myelin associated glycoprotein
  • Synonyms
    GMA, SIGLEC4, SIGLEC-4A, SIGLEC4A, S-MAG, SPG75
  • Links
    NCBI Gene ID: 4099
    neXtProt AC: NX_P20916
    UniProt: P20916

  • Chr Location
    19q13.12; chr19:35292125-35313807 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 5 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit delayed CNS myelination, late myelin degeneration in peripheral nerves, hypomyelination of optic nerves, and subtle intention tremors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    79
  • cDNA Data
    20
  • Literature Summary
    58
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036634 Ensembl Gene Model | MGI Sequence Detail 15698 C57BL/6J ±  kb
transcript ENSMUST00000191081 Ensembl | MGI Sequence Detail 2007 Not Applicable  
polypeptide ENSMUSP00000139881 Ensembl | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 7
    cDNA 25
    Primer pair 6
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10172, MGD-MRK-12105
References
more
  • Summaries
    All 210
    Developmental Gene Expression 58
    Gene Ontology 22
    Phenotypes 57
  • Earliest
    J:31033 Gilman AG, G proteins and dual control of adenylate cyclase. Cell. 1984 Mar;36(3):577-9
  • Latest
    J:347284 Zhang Y, et al., PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Cell Rep. 2024 Mar 26;43(3):113930
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory